The Protective Effect of a Unique Mix of Polyphenols and Micronutrients against Neurodegeneration Induced by an In Vitro Model of Parkinson's Disease.

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作者： Francesca,Pacifici ^[1] ; Chiara,Salimei ^[1] ; Donatella,Pastore ^[2] ; Gina,Malatesta ^[3] ; Camillo,Ricordi ^[4] ; Giulia,Donadel ^[5] ; Alfonso,Bellia ^[1] ; Valentina,Rovella ^[6] ; Marco,Tafani ^[1] ; Enrico,Garaci ^[6] ; Manfredi,Tesauro ^[7] ; Davide,Lauro ^[2] ; Nicola,Di Daniele ^[1] ; David,Della-Morte ^[5]

作者单位： Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy. ^[1] Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy. ^[2] Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy. ^[3] Cell Transplant Center, Diabetes Research Institute, School of Medicine, University of Miami Miller, Miami, FL 33136, USA. ^[4] Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy. ^[5] Department of Medical Sciences, Fondazione Policlinico Tor Vergata, 00133 Rome, Italy. ^[6] Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy. ^[7] Department of Neurology, Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. ^[8] Interdisciplinary Center for Advanced Studies on Lab-on-Chip and Organ-on-Chip Applications (ICLOC), University of Rome Tor Vergata, 00133 Rome, Italy. ^[9]

关键词 Parkinson’s disease SIRT1 inflammation oxidative stress polyphenols

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);小鼠(Mice);微量营养系(Micronutrients);羟多巴胺(Oxidopamine);帕金森病(Parkinson Disease)

DOI 10.3390/ijms23063110

PMID 35328530

发布时间 2022-04-08

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