Targeted-detection and sequential-treatment of small hepatocellular carcinoma in the complex liver environment by GPC-3-targeted nanoparticles.

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作者： Han,Deng ^[1] ; Wenting,Shang ^[2] ; Kun,Wang ^[2] ; Kunxiong,Guo ^[2] ; Yu,Liu ^[1] ; Jie,Tian ^[2] ; Chihua,Fang ^[2]

作者单位： Department of Hepatobiliary Surgery, Institute for Digital Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. ^[1] CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. ^[2] Department of Hepatobiliary Surgery, Institute for Digital Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. jie.tian@ia.ac.cn. ^[3] CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. jie.tian@ia.ac.cn. ^[4] Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, Beihang University, Beijing, 100191, China. jie.tian@ia.ac.cn. ^[5] Department of Hepatobiliary Surgery, Institute for Digital Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. zjyyfangchihua@smu.edu.cn. ^[6] Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou, 510280, China. zjyyfangchihua@smu.edu.cn. ^[7]

关键词 Complex liver environment Dynamic contrast-enhanced photoacoustic imaging Sequential catalysis-targeted therapy Small hepatocellular carcinoma Targeted detection

主题词动物(Animals);癌, 肝细胞(Carcinoma, Hepatocellular);人类(Humans);肝肿瘤(Liver Neoplasms);磁共振成像(Magnetic Resonance Imaging);小鼠(Mice);纳米粒子(Nanoparticles)

DOI 10.1186/s12951-022-01378-w

PMID 35331259

发布时间 2022-04-01

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准确一般字义偏差语意偏离译文作用小提交