Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells.

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作者： Junwan,Lu ^[1] ; Yujie,Li ^[2] ; Shiwei,Gong ^[1] ; Jiaxin,Wang ^[1] ; Xiaoang,Lu ^[3] ; Qiumei,Jin ^[1] ; Bin,Lu ^[1] ; Qin,Chen ^[1]

作者单位： Protein Quality Control and Diseases Laboratory, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. ^[1] School of Medicine, Jinhua Polytechnic, Jinhua, 321007, China. ^[2] Department of Laboratory Medicine, Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, Wuhan, 430030, Hubei, China. ^[3] Protein Quality Control and Diseases Laboratory, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. lubmito@wmu.edu.cn. ^[4] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. lubmito@wmu.edu.cn. ^[5] Department of Intensive Care, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. chenqin@wmu.edu.cn. ^[6]

关键词 Cellular bioenergetics Ciclopirox Endoplasmic reticulum stress Epithelial-mesenchymal transition Non-small cell lung cancer