The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals.

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第一作者： Fenghua,Wang

第一单位： School of Life Sciences, Tianjin University, Tianjin 300072, China.;Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.;Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.

作者： Fenghua,Wang ^[1] ; Cheng,Chen ^[2] ; Zefang,Wang ^[2] ; Xu,Han ^[3] ; Peidian,Shi ^[3] ; Kaixuan,Zhou ^[4] ; Xiaomei,Liu ^[4] ; Yunjie,Xiao ^[3] ; Yan,Cai ^[4] ; Jinhai,Huang ^[3] ; Lei,Zhang ^[3] ; Haitao,Yang ^[5]

作者单位： School of Life Sciences, Tianjin University, Tianjin 300072, China.;Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.;Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China. ^[1] School of Life Sciences, Tianjin University, Tianjin 300072, China.;Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China. ^[2] School of Life Sciences, Tianjin University, Tianjin 300072, China. ^[3] Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China. ^[4] School of Life Sciences, Tianjin University, Tianjin 300072, China.;Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.;Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China. ^[5]

关键词 broad-spectrum antivirals coronaviruses main protease porcine deltacoronavirus

主题词动物(Animals);抗病毒药(Antiviral Agents);冠状病毒属(Coronavirus);肽水解酶类(Peptide Hydrolases);猪(Swine)

DOI 10.3390/v14030486

PMID 35336895

发布时间 2022-04-01

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