Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays.

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作者： Alice,Parodi ^[1] ; Giada,Righetti ^[2] ; Emanuela,Pesce ^[3] ; Annalisa,Salis ^[1] ; Valeria,Tomati ^[3] ; Cristina,Pastorino ^[4] ; Bruno,Tasso ^[2] ; Mirko,Benvenuti ^[1] ; Gianluca,Damonte ^[1] ; Nicoletta,Pedemonte ^[3] ; Elena,Cichero ^[2] ; Enrico,Millo ^[1]

作者单位： Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV, 1, 16132 Genoa, Italy. ^[1] Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy. ^[2] UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. ^[3] Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DI-NOGMI), University of Genoa, 16132 Genoa, Italy. ^[4]

关键词 CFTR corrector F508del-CFTR VX-809 aminoarylthiazole cystic fibrosis docking

DOI 10.3390/ph15030274

PMID 35337072

发布时间 2022-03-29

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