Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

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作者： Shawn B,Egri ^[1] ; Christna,Ouch ^[2] ; Hui-Ting,Chou ^[3] ; Zhiheng,Yu ^[3] ; Kangkang,Song ^[2] ; Chen,Xu ^[2] ; Kuang,Shen ^[4]

作者单位： Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation St, Worcester, MA 01605, USA. ^[1] Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Chan Medical School, 364 Plantation St, Worcester, MA 01605, USA. ^[2] Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA. ^[3] Program in Molecular Medicine, University of Massachusetts Chan Medical School, 373 Plantation St, Worcester, MA 01605, USA. Electronic address: kuang.shen@umassmed.edu. ^[4]

关键词 GAP GATOR1 Rag GTPase enzyme mechanism mTOR complex 1 mTORC1 nutrient sensing

主题词氨基酸类(Amino Acids);冷冻电子显微镜检查(Cryoelectron Microscopy);GTP酶激活蛋白质类(GTPase-Activating Proteins);人类(Humans);细胞内膜(Intracellular Membranes);溶酶体(Lysosomes);单体GTP结合蛋白质类(Monomeric GTP-Binding Proteins)

DOI 10.1016/j.molcel.2022.03.002

PMID 35338845

发布时间 2023-09-16

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