Porcine β-defensin 2 confers enhanced resistance to swine flu infection in transgenic pigs and alleviates swine influenza virus-induced apoptosis possibly through interacting with host SLC25A4.

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作者： Jing,Huang ^[1] ; Xiao,Liu ^[2] ; Yufan,Sun ^[2] ; Chao,Huang ^[2] ; Antian,Wang ^[2] ; Jiajia,Xu ^[2] ; Hongbo,Zhou ^[2] ; Lu,Li ^[3] ; Rui,Zhou ^[4]

作者单位： State Key Laboratory of Agricultural Microbiology, Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; International Research Center for Animal Disease, Ministry of Science and Technology of China, Wuhan, 430070, China; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, 55108, USA. ^[1] State Key Laboratory of Agricultural Microbiology, Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; International Research Center for Animal Disease, Ministry of Science and Technology of China, Wuhan, 430070, China. ^[2] State Key Laboratory of Agricultural Microbiology, Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; International Research Center for Animal Disease, Ministry of Science and Technology of China, Wuhan, 430070, China. Electronic address: lilu@mail.hzau.edu.cn. ^[3] State Key Laboratory of Agricultural Microbiology, Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; International Research Center for Animal Disease, Ministry of Science and Technology of China, Wuhan, 430070, China. Electronic address: rzhou@mail.hzau.edu.cn. ^[4]

关键词 Antimicrobial peptides Apoptosis Disease-resistance Porcine β-defensin 2 SLC25A4 Swine influenza virus