Metabolomics reveals that CAF-derived lipids promote colorectal cancer peritoneal metastasis by enhancing membrane fluidity.

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第一作者： Shaoyong,Peng

第一单位： Department of Colon and Rectum Surgery, The Sixth Affiliated Hospital (Guangdong Gastrointestinal and Anal Hospital), Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, 510655, China.;Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital (Guangdong Gastrointestinal and Anal Hospital), Sun Yat-sen University, Guangzhou, Guangdong, 510655, China.

作者： Shaoyong,Peng ^[1] ; Yingjie,Li ^[2] ; Meijin,Huang ^[3] ; Guannan,Tang ^[2] ; Yumo,Xie ^[2] ; Daici,Chen ^[4] ; Yumin,Hu ^[5] ; Tiantian,Yu ^[5] ; Jian,Cai ^[3] ; Zixu,Yuan ^[3] ; Huaiming,Wang ^[3] ; Hui,Wang ^[3] ; Yanxin,Luo ^[1] ; Xiaoxia,Liu ^[2]

作者单位： Department of Colon and Rectum Surgery, The Sixth Affiliated Hospital (Guangdong Gastrointestinal and Anal Hospital), Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, 510655, China.;Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital (Guangdong Gastrointestinal and Anal Hospital), Sun Yat-sen University, Guangzhou, Guangdong, 510655, China. ^[1] Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital (Guangdong Gastrointestinal and Anal Hospital), Sun Yat-sen University, Guangzhou, Guangdong, 510655, China. ^[2] Department of Colon and Rectum Surgery, The Sixth Affiliated Hospital (Guangdong Gastrointestinal and Anal Hospital), Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, 510655, China. ^[3] Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital (Guangdong Gastrointestinal and Anal Hospital), Sun Yat-sen University, Guangzhou, Guangdong, 510655, China.;Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, China. ^[4] Sun Yat-sen University Metabolomics Center, Guangzhou, Guangdong, 510080, China. ^[5]

关键词 C16:0 Lipidomics cancer-associated fibroblasts (CAFs)colorectal cancer peritoneal metastasis glucose metabolism metabolomics