Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2.

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第一作者： Zhimin,Gao

第一单位： Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences& The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou511436, China.

作者： Zhimin,Gao ^[1] ; Wei,Yi ^[1] ; Junyuan,Tang ^[1] ; Yuling,Sun ^[1] ; Jianrong,Huang ^[1] ; Tian,Lan ^[2] ; Xiaoyan,Dai ^[1] ; Suowen,Xu ^[3] ; Zheng-Gen,Jin ^[4] ; Xiaoqian,Wu ^[1]

作者单位： Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences& The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou511436, China. ^[1] Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. ^[2] Department of Endocrinology and Metabolism, The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei 230037, China. ^[3] Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. ^[4]

关键词 Acetaminophen Acute liver injury Mitophagy Nrf2 Urolithin A

主题词动物(Animals);小鼠(Mice);醋氨酚(Acetaminophen);香豆素类(Coumarins);肝(Liver);NF-E2相关因子2(NF-E2-Related Factor 2);氧化性应激(Oxidative Stress)

DOI 10.7150/ijbs.69116

PMID 35342347

发布时间 2022-12-13

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