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Synthesis of Hybrid Tripeptide Peptidomimetics Containing Dehydroamino Acid and Aminophosphonic Acid in the Chain and Evaluation of Their Activity toward Cathepsin C.

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第一作者： Michał Paweł,Jewgiński

第一单位： Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspianskiego 27, 50-370, Wroclaw, Poland.

作者： Michał Paweł,Jewgiński ^[1] ; Maciej,Makowski ^[2] ; Małgorzata,Pawełczak ^[2] ; Waldemar,Goldeman ^[3] ; Alicja,Trojanowska-Laskowska ^[2] ; Paweł,Kafarski ^[4] ; Rafał,Latajka ^[1]

作者单位： Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspianskiego 27, 50-370, Wroclaw, Poland. ^[1] Faculty of Chemistry, University of Opole, Oleska 48, 45-052, Opole, Poland. ^[2] Department of Organic and Medical Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspianskiego 27, 50-370, Wroclaw, Poland. ^[3] Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspianskiego 27, 50-370, Wroclaw, Poland.;Faculty of Chemistry, University of Opole, Oleska 48, 45-052, Opole, Poland. ^[4]

关键词 DPPI dehydropeptides inhibitors molecular modeling phosphonopeptides structure-activity relation

医学主题词组织蛋白酶C(Cathepsin C);分子构象(Molecular Conformation);肽类(Peptides);多肽模拟物(Peptidomimetics)

DOI 10.1002/cbdv.202101019

PMID 35343636

发布时间 2022-05-23

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