In-silico and in-vitro investigation of STAT3-PIM1 heterodimeric complex: Its mechanism and inhibition by curcumin for cancer therapeutics.

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第一作者： Sutapa,Mahata

第一单位： Department of Pathology and Cancer Screening, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India.

作者： Sutapa,Mahata ^[1] ; Santosh Kumar,Behera ^[2] ; Sunil,Kumar ^[3] ; Pranab Kumar,Sahoo ^[1] ; Sinjini,Sarkar ^[1] ; Mobashar Hussain Urf Turabe,Fazil ^[4] ; Vilas D,Nasare ^[5]

作者单位： Department of Pathology and Cancer Screening, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India. ^[1] Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gandhinagar 382355, Gujarat, India. ^[2] ICAR-IASRI, Library Avenue Pusa, New Delhi 110012, India. ^[3] Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, 11 Mandalay Road, Singapore. ^[4] Department of Pathology and Cancer Screening, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India. Electronic address: vilas.dr@gmail.com. ^[5]

关键词 Cancer Curcumin Molecular docking Molecular dynamics simulations PIM1 STAT3

主题词姜黄素(Curcumin);人类(Humans);分子动力学模拟(Molecular Dynamics Simulation);肿瘤(Neoplasms);原癌基因蛋白质c-pim-1(Proto-Oncogene Proteins c-pim-1);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction)

DOI 10.1016/j.ijbiomac.2022.03.137

PMID 35346675

发布时间 2022-05-10

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