CD4<sup>+</sup> T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1-Dependent.

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作者： Iulia,Popescu ^[1] ; Mark E,Snyder ^[1] ; Carlo J,Iasella ^[2] ; Stefanie J,Hannan ^[1] ; Ritchie,Koshy ^[1] ; Robin,Burke ^[1] ; Antu,Das ^[1] ; Mark J,Brown ^[1] ; Emily J,Lyons ^[1] ; Sophia C,Lieber ^[1] ; Xiaoping,Chen ^[1] ; John C,Sembrat ^[1] ; Payal,Bhatt ^[2] ; Evan,Deng ^[2] ; Xiaojing,An ^[1] ; Kelsey,Linstrum ^[3] ; Georgios,Kitsios ^[1] ; Ioannis,Konstantinidis ^[1] ; Melissa,Saul ^[4] ; Daniel J,Kass ^[1] ; Jonathan K,Alder ^[1] ; Bill B,Chen ^[1] ; Elizabeth A,Lendermon ^[5] ; Silpa,Kilaru ^[1] ; Bruce,Johnson ^[1] ; Joseph M,Pilewski ^[1] ; Joseph E,Kiss ^[1] ; Alan H,Wells ^[6] ; Alison,Morris ^[7] ; Bryan J,McVerry ^[1] ; Deborah K,McMahon ^[1] ; Darrell J,Triulzi ^[8] ; Kong,Chen ^[6] ; Pablo G,Sanchez ^[1] ; John F,McDyer ^[9]

作者单位： Division of Pulmonary, Allergy, and Critical Care Medicine. ^[1] Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania. ^[2] Department of Critical Care Medicine. ^[3] Department of Medicine. ^[4] Aging Institute. ^[5] Division of Transfusion Medicine. ^[6] Division of Laboratory Medicine, Department of Pathology. ^[7] Division of Infectious Diseases, and. ^[8] Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and. ^[9]

关键词 CD4+ T cells COVID-19 SARS-CoV-2 infection TNF-α lymphopenia