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DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists.

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作者单位: Duke University School of Medicine, Department of Surgery, Division of Surgical Sciences, USA. [1] Duke University, Department of Biomedical Engineering, Pratt School of Engineering, USA; Duke University, Graduate School, USA. [2] Duke University, Graduate School, USA; Duke University School of Medicine, Department of Pharmacology and Cancer Biology, USA. [3] Duke University, Graduate School, USA. [4] Columbia University, Department of Biomedical Engineering, USA. [5] Duke University Center for Genomic and Computational Biology, RNA Sequencing Core, USA. [6] Duke University School of Medicine, Department of Medicine, Division of Pulmonary Medicine, USA. [7] Duke University, Department of Biomedical Engineering, Pratt School of Engineering, USA. [8] Duke University School of Medicine, Department of Surgery, Division of Surgical Sciences, USA; Duke University School of Medicine, Department of Pathology, USA; Duke University School of Medicine, Department of Neurosurgery, USA. Electronic address: smita.nair@duke.edu. [9] Duke University School of Medicine, Department of Surgery, Division of Surgical Sciences, USA; Duke University, Department of Biomedical Engineering, Pratt School of Engineering, USA; Duke University School of Medicine, Department of Pharmacology and Cancer Biology, USA; Duke University School of Medicine, Department of Neurosurgery, USA. Electronic address: bruce.sullenger@duke.edu. [10]
DOI 10.1016/j.biomaterials.2022.121393
PMID 35349874
发布时间 2023-09-06
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