AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model.

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第一作者： Marika,Marino

第一单位： VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.

作者： Marika,Marino ^[1] ; Lujia,Zhou ^[2] ; Melvin Y,Rincon ^[1] ; Zsuzsanna,Callaerts-Vegh ^[2] ; Jens,Verhaert ^[1] ; Jérôme,Wahis ^[2] ; Eline,Creemers ^[3] ; Lidia,Yshii ^[1] ; Keimpe,Wierda ^[2] ; Takashi,Saito ^[1] ; Catherine,Marneffe ^[2] ; Iryna,Voytyuk ^[1] ; Yessica,Wouters ^[2] ; Maarten,Dewilde ^[4] ; Sandra I,Duqué ^[1] ; Cécile,Vincke ^[2] ; Yona,Levites ^[5] ; Todd E,Golde ^[1] ; Takaomi C,Saido ^[2] ; Serge,Muyldermans ^[4] ; Adrian,Liston ^[6] ; Bart,De Strooper ^[1] ; Matthew G,Holt ^[2]

作者单位： VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium. ^[1] Department of Neurosciences, KU Leuven, Leuven, Belgium. ^[2] Faculty of Psychology, Laboratory of Biological Psychology, KU Leuven, Leuven, Belgium. ^[3] Electrophysiology Expertise Unit, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium. ^[4] Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. ^[5] Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. ^[6] Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium. ^[7] Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA. ^[8] Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Japan. ^[9] Immunology Programme, The Babraham Institute, Cambridge, UK. ^[10] UK Dementia Research institute at UCL, London, UK. ^[11] Leuven Brain Institute, Leuven, Belgium. ^[12] Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal. ^[13]

关键词 AAV Alzheimer’s disease VHH anti-BACE1