首页> Frontiers in immunology> IDO1 Inhibition Reduces Immune Cell Exclusion Through Inducing Cell Migration While PD-1 Blockage Increases IL-6 and -8 Secretion From T Cells in Head and Neck Cancer.

IDO1 Inhibition Reduces Immune Cell Exclusion Through Inducing Cell Migration While PD-1 Blockage Increases IL-6 and -8 Secretion From T Cells in Head and Neck Cancer.

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第一作者： Meri,Sieviläinen

第一单位： Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.;Translational Immunology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

作者： Meri,Sieviläinen ^[1] ; Jordan,Saavalainen ^[2] ; Shady,Adnan-Awad ^[3] ; Tuula,Salo ^[4] ; Ahmed,Al-Samadi ^[1]

作者单位： Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.;Translational Immunology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. ^[1] Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.;School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom. ^[2] Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.;Hematology Research Unit, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Comprehensive Cancer Center, Helsinki, Finland. ^[3] Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.;Translational Immunology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.;Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.;Medical Research Center, Oulu University Hospital, Oulu, Finland.;Department of Pathology, Helsinki University Hospital (HUS), Helsinki, Finland. ^[4]

关键词 IDO1 PD-1 PD-L1 head and neck squamous cell carcinoma immune checkpoint inhibitors immunotherapy microfluidic chip

医学主题词 CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);癌, 鳞状细胞(Carcinoma, Squamous Cell);细胞运动(Cell Movement);头颈部肿瘤(Head and Neck Neoplasms);人类(Humans);白细胞介素6(Interleukin-6);舌肿瘤(Tongue Neoplasms)

DOI 10.3389/fimmu.2022.812822

PMID 35359980

发布时间 2022-05-20

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