Current Status, Barriers, and Future Directions for Humanized Mouse Models to Evaluate Stem Cell-Based Islet Cell Transplant.

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第一作者： Kevin,Verhoeff

第一单位： Department of Surgery, University of Alberta, Edmonton, AB, Canada.

作者： Kevin,Verhoeff ^[1] ; Braulio A,Marfil-Garza ^[2] ; Nerea,Cuesta-Gomez ^[3] ; Ila,Jasra ^[3] ; Nidheesh,Dadheech ^[3] ; A M James,Shapiro ^[4]

作者单位： Department of Surgery, University of Alberta, Edmonton, AB, Canada. ^[1] Department of Surgery, University of Alberta, Edmonton, AB, Canada.;National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico.;CHRISTUS-LatAm Hub - Excellence and Innovation Center, Monterrey, Mexico. ^[2] Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. ^[3] Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. jshapiro@ualberta.ca.;Department of Surgery and Clinical Islet Transplant Programme, University of Alberta, Edmonton, AB, Canada. jshapiro@ualberta.ca.;Li Ka Shing Centre for Health Research Innovation, Edmonton, AB, Canada. jshapiro@ualberta.ca. ^[4]

关键词 Diabetes Humanized mouse model Immunosuppression Inducible pluripotent stem cells Islet cell transplant Transplant

主题词动物(Animals);糖尿病, 1型(Diabetes Mellitus, Type 1);造血干细胞移植(Hematopoietic Stem Cell Transplantation);人类(Humans);胰岛(Islets of Langerhans);胰岛移植(Islets of Langerhans Transplantation);小鼠(Mice)

DOI 10.1007/5584_2022_711

PMID 35362861

发布时间 2022-08-01

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