换一批
第一作者：
Céline,Bellenguez
第一单位：
Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr.
作者：
Céline,Bellenguez [1]
;
Fahri,Küçükali [2]
;
Iris E,Jansen [3]
;
Luca,Kleineidam [4]
;
Sonia,Moreno-Grau [5]
;
Najaf,Amin [6]
;
Adam C,Naj [7]
;
Rafael,Campos-Martin [8]
;
Benjamin,Grenier-Boley [9]
;
Victor,Andrade [10]
;
Peter A,Holmans [11]
;
Anne,Boland [12]
;
Vincent,Damotte [9]
;
Sven J,van der Lee [13]
;
Marcos R,Costa [14]
;
Teemu,Kuulasmaa [15]
;
Qiong,Yang [16]
;
Itziar,de Rojas [5]
;
Joshua C,Bis [17]
;
Amber,Yaqub [18]
;
Ivana,Prokic [18]
;
Julien,Chapuis [9]
;
Shahzad,Ahmad [19]
;
Vilmantas,Giedraitis [20]
;
Dag,Aarsland [21]
;
Pablo,Garcia-Gonzalez [5]
;
Carla,Abdelnour [5]
;
Emilio,Alarcón-Martín [22]
;
Daniel,Alcolea [23]
;
Montserrat,Alegret [5]
;
Ignacio,Alvarez [24]
;
Victoria,Álvarez [25]
;
Nicola J,Armstrong [26]
;
Anthoula,Tsolaki [27]
;
Carmen,Antúnez [28]
;
Ildebrando,Appollonio [29]
;
Marina,Arcaro [30]
;
Silvana,Archetti [31]
;
Alfonso Arias,Pastor [32]
;
Beatrice,Arosio [33]
;
Lavinia,Athanasiu [34]
;
Henri,Bailly [35]
;
Nerisa,Banaj [36]
;
Miquel,Baquero [37]
;
Sandra,Barral [38]
;
Alexa,Beiser [39]
;
Ana Belén,Pastor [40]
;
Jennifer E,Below [41]
;
Penelope,Benchek [42]
;
Luisa,Benussi [43]
;
Claudine,Berr [44]
;
Céline,Besse [12]
;
Valentina,Bessi [45]
;
Giuliano,Binetti [46]
;
Alessandra,Bizarro [47]
;
Rafael,Blesa [23]
;
Mercè,Boada [5]
;
Eric,Boerwinkle [48]
;
Barbara,Borroni [49]
;
Silvia,Boschi [50]
;
Paola,Bossù [51]
;
Geir,Bråthen [52]
;
Jan,Bressler [53]
;
Catherine,Bresner [11]
;
Henry,Brodaty [54]
;
Keeley J,Brookes [55]
;
Luis Ignacio,Brusco [56]
;
Dolores,Buiza-Rueda [57]
;
Katharina,Bûrger [58]
;
Vanessa,Burholt [59]
;
William S,Bush [60]
;
Miguel,Calero [61]
;
Laura B,Cantwell [62]
;
Geneviève,Chene [63]
;
Jaeyoon,Chung [64]
;
Michael L,Cuccaro [65]
;
Ángel,Carracedo [66]
;
Roberta,Cecchetti [67]
;
Laura,Cervera-Carles [23]
;
Camille,Charbonnier [68]
;
Hung-Hsin,Chen [69]
;
Caterina,Chillotti [70]
;
Simona,Ciccone [71]
;
Jurgen A H R,Claassen [72]
;
Christopher,Clark [73]
;
Elisa,Conti [74]
;
Anaïs,Corma-Gómez [75]
;
Emanuele,Costantini [76]
;
Carlo,Custodero [77]
;
Delphine,Daian [12]
;
Maria Carolina,Dalmasso [8]
;
Antonio,Daniele [76]
;
Efthimios,Dardiotis [78]
;
Jean-François,Dartigues [79]
;
Peter Paul,de Deyn [80]
;
Katia,de Paiva Lopes [81]
;
Lot D,de Witte [82]
;
Stéphanie,Debette [79]
;
Jürgen,Deckert [83]
;
Teodoro,Del Ser [40]
;
Nicola,Denning [84]
;
Anita,DeStefano [85]
;
Martin,Dichgans [86]
;
Janine,Diehl-Schmid [87]
;
Mónica,Diez-Fairen [24]
;
Paolo Dionigi,Rossi [71]
;
Srdjan,Djurovic [34]
;
Emmanuelle,Duron [35]
;
Emrah,Düzel [88]
;
Carole,Dufouil [63]
;
Gudny,Eiriksdottir [89]
;
Sebastiaan,Engelborghs [90]
;
Valentina,Escott-Price [91]
;
Ana,Espinosa [5]
;
Michael,Ewers [58]
;
Kelley M,Faber [92]
;
Tagliavini,Fabrizio [93]
;
Sune Fallgaard,Nielsen [94]
;
David W,Fardo [95]
;
Lucia,Farotti [96]
;
Chiara,Fenoglio [97]
;
Marta,Fernández-Fuertes [75]
;
Raffaele,Ferrari [98]
;
Catarina B,Ferreira [99]
;
Evelyn,Ferri [71]
;
Bertrand,Fin [12]
;
Peter,Fischer [100]
;
Tormod,Fladby [101]
;
Klaus,Fließbach [102]
;
Bernard,Fongang [103]
;
Myriam,Fornage [104]
;
Juan,Fortea [23]
;
Tatiana M,Foroud [92]
;
Silvia,Fostinelli [43]
;
Nick C,Fox [105]
;
Emlio,Franco-Macías [106]
;
María J,Bullido [107]
;
Ana,Frank-García [108]
;
Lutz,Froelich [109]
;
Brian,Fulton-Howard [110]
;
Daniela,Galimberti [111]
;
Jose Maria,García-Alberca [112]
;
Pablo,García-González [113]
;
Sebastian,Garcia-Madrona [114]
;
Guillermo,Garcia-Ribas [114]
;
Roberta,Ghidoni [43]
;
Ina,Giegling [115]
;
Giaccone,Giorgio [93]
;
Alison M,Goate [110]
;
Oliver,Goldhardt [87]
;
Duber,Gomez-Fonseca [116]
;
Antonio,González-Pérez [117]
;
Caroline,Graff [118]
;
Giulia,Grande [119]
;
Emma,Green [120]
;
Timo,Grimmer [87]
;
Edna,Grünblatt [121]
;
Michelle,Grunin [122]
;
Vilmundur,Gudnason [123]
;
Tamar,Guetta-Baranes [124]
;
Annakaisa,Haapasalo [125]
;
Georgios,Hadjigeorgiou [126]
;
Jonathan L,Haines [60]
;
Kara L,Hamilton-Nelson [127]
;
Harald,Hampel [128]
;
Olivier,Hanon [35]
;
John,Hardy [129]
;
Annette M,Hartmann [115]
;
Lucrezia,Hausner [109]
;
Janet,Harwood [11]
;
Stefanie,Heilmann-Heimbach [130]
;
Seppo,Helisalmi [131]
;
Michael T,Heneka [132]
;
Isabel,Hernández [5]
;
Martin J,Herrmann [83]
;
Per,Hoffmann [130]
;
Clive,Holmes [133]
;
Henne,Holstege [13]
;
Raquel Huerto,Vilas [32]
;
Marc,Hulsman [13]
;
Jack,Humphrey [134]
;
Geert Jan,Biessels [135]
;
Xueqiu,Jian [103]
;
Charlotte,Johansson [136]
;
Gyungah R,Jun [64]
;
Yuriko,Kastumata [137]
;
John,Kauwe [138]
;
Patrick G,Kehoe [139]
;
Lena,Kilander [140]
;
Anne Kinhult,Ståhlbom [136]
;
Miia,Kivipelto [141]
;
Anne,Koivisto [142]
;
Johannes,Kornhuber [143]
;
Mary H,Kosmidis [144]
;
Walter A,Kukull [145]
;
Pavel P,Kuksa [146]
;
Brian W,Kunkle [126]
;
Amanda B,Kuzma [62]
;
Carmen,Lage [147]
;
Erika J,Laukka [148]
;
Lenore,Launer [149]
;
Alessandra,Lauria [47]
;
Chien-Yueh,Lee [146]
;
Jenni,Lehtisalo [150]
;
Ondrej,Lerch [151]
;
Alberto,Lleó [23]
;
William,Longstreth [152]
;
Oscar,Lopez [153]
;
Adolfo Lopez,de Munain [154]
;
Seth,Love [139]
;
Malin,Löwemark [140]
;
Lauren,Luckcuck [11]
;
Kathryn L,Lunetta [15]
;
Yiyi,Ma [155]
;
Juan,Macías [75]
;
Catherine A,MacLeod [156]
;
Wolfgang,Maier [132]
;
Francesca,Mangialasche [157]
;
Marco,Spallazzi [158]
;
Marta,Marquié [5]
;
Rachel,Marshall [11]
;
Eden R,Martin [127]
;
Angel Martín,Montes [108]
;
Carmen Martínez,Rodríguez [159]
;
Carlo,Masullo [160]
;
Richard,Mayeux [161]
;
Simon,Mead [162]
;
Patrizia,Mecocci [67]
;
Miguel,Medina [163]
;
Alun,Meggy [84]
;
Shima,Mehrabian [164]
;
Silvia,Mendoza [165]
;
Manuel,Menéndez-González [159]
;
Pablo,Mir [166]
;
Susanne,Moebus [167]
;
Merel,Mol [168]
;
Laura,Molina-Porcel [169]
;
Laura,Montrreal [113]
;
Laura,Morelli [170]
;
Fermin,Moreno [154]
;
Kevin,Morgan [171]
;
Thomas,Mosley [172]
;
Markus M,Nöthen [130]
;
Carolina,Muchnik [173]
;
Shubhabrata,Mukherjee [174]
;
Benedetta,Nacmias [175]
;
Tiia,Ngandu [176]
;
Gael,Nicolas [68]
;
Børge G,Nordestgaard [177]
;
Robert,Olaso [12]
;
Adelina,Orellana [5]
;
Michela,Orsini [76]
;
Gemma,Ortega [5]
;
Alessandro,Padovani [178]
;
Caffarra,Paolo [179]
;
Goran,Papenberg [119]
;
Lucilla,Parnetti [96]
;
Florence,Pasquier [180]
;
Pau,Pastor [24]
;
Gina,Peloso [39]
;
Alba,Pérez-Cordón [113]
;
Jordi,Pérez-Tur [181]
;
Pierre,Pericard [182]
;
Oliver,Peters [183]
;
Yolande A L,Pijnenburg [184]
;
Juan A,Pineda [75]
;
Gerard,Piñol-Ripoll [32]
;
Claudia,Pisanu [185]
;
Thomas,Polak [83]
;
Julius,Popp [186]
;
Danielle,Posthuma [187]
;
Josef,Priller [188]
;
Raquel,Puerta [113]
;
Olivier,Quenez [68]
;
Inés,Quintela [189]
;
Jesper Qvist,Thomassen [190]
;
Alberto,Rábano [163]
;
Innocenzo,Rainero [49]
;
Farid,Rajabli [127]
;
Inez,Ramakers [191]
;
Luis M,Real [192]
;
Marcel J T,Reinders [193]
;
Christiane,Reitz [194]
;
Dolly,Reyes-Dumeyer [195]
;
Perry,Ridge [196]
;
Steffi,Riedel-Heller [197]
;
Peter,Riederer [198]
;
Natalia,Roberto [113]
;
Eloy,Rodriguez-Rodriguez [147]
;
Arvid,Rongve [199]
;
Irene Rosas,Allende [25]
;
Maitée,Rosende-Roca [5]
;
Jose Luis,Royo [200]
;
Elisa,Rubino [201]
;
Dan,Rujescu [115]
;
María Eugenia,Sáez [117]
;
Paraskevi,Sakka [202]
;
Ingvild,Saltvedt [203]
;
Ángela,Sanabria [5]
;
María Bernal,Sánchez-Arjona [106]
;
Florentino,Sanchez-Garcia [204]
;
Pascual Sánchez,Juan [147]
;
Raquel,Sánchez-Valle [205]
;
Sigrid B,Sando [206]
;
Chloé,Sarnowski [207]
;
Claudia L,Satizabal [208]
;
Michela,Scamosci [67]
;
Nikolaos,Scarmeas [209]
;
Elio,Scarpini [111]
;
Philip,Scheltens [184]
;
Norbert,Scherbaum [210]
;
Martin,Scherer [211]
;
Matthias,Schmid [212]
;
Anja,Schneider [132]
;
Jonathan M,Schott [105]
;
Geir,Selbæk [213]
;
Davide,Seripa [214]
;
Manuel,Serrano [215]
;
Jin,Sha [216]
;
Alexey A,Shadrin [34]
;
Olivia,Skrobot [139]
;
Susan,Slifer [127]
;
Gijsje J L,Snijders [82]
;
Hilkka,Soininen [217]
;
Vincenzo,Solfrizzi [77]
;
Alina,Solomon [218]
;
Yeunjoo,Song [122]
;
Sandro,Sorbi [175]
;
Oscar,Sotolongo-Grau [113]
;
Gianfranco,Spalletta [36]
;
Annika,Spottke [219]
;
Alessio,Squassina [220]
;
Eystein,Stordal [221]
;
Juan Pablo,Tartan [113]
;
Lluís,Tárraga [5]
;
Niccolo,Tesí [13]
;
Anbupalam,Thalamuthu [26]
;
Tegos,Thomas [27]
;
Giuseppe,Tosto [222]
;
Latchezar,Traykov [164]
;
Lucio,Tremolizzo [29]
;
Anne,Tybjærg-Hansen [223]
;
Andre,Uitterlinden [224]
;
Abbe,Ullgren [136]
;
Ingun,Ulstein [225]
;
Sergi,Valero [5]
;
Otto,Valladares [146]
;
Christine Van,Broeckhoven [226]
;
Jeffery,Vance [65]
;
Badri N,Vardarajan [227]
;
Aad,van der Lugt [228]
;
Jasper Van,Dongen [2]
;
Jeroen,van Rooij [229]
;
John,van Swieten [168]
;
Rik,Vandenberghe [230]
;
Frans,Verhey [191]
;
Jean-Sébastien,Vidal [35]
;
Jonathan,Vogelgsang [231]
;
Martin,Vyhnalek [151]
;
Michael,Wagner [132]
;
David,Wallon [232]
;
Li-San,Wang [146]
;
Ruiqi,Wang [233]
;
Leonie,Weinhold [234]
;
Jens,Wiltfang [235]
;
Gill,Windle [156]
;
Bob,Woods [156]
;
Mary,Yannakoulia [236]
;
Habil,Zare [103]
;
Yi,Zhao [146]
;
Xiaoling,Zhang [237]
;
Congcong,Zhu [237]
;
Miren,Zulaica [238]
;
EADB [239]
;
GR@ACE [240]
;
DEGESCO [18]
;
EADI [134]
;
GERAD [26]
;
Demgene [26]
;
FinnGen [132]
;
ADGC [18]
;
CHARGE [99]
;
Lindsay A,Farrer [241]
;
Bruce M,Psaty [27]
;
Mohsen,Ghanbari [125]
;
Towfique,Raj [9]
;
Perminder,Sachdev [242]
;
Karen,Mather [223]
;
Frank,Jessen [23]
;
M Arfan,Ikram [12]
;
Alexandre,de Mendonça [93]
;
Jakub,Hort [208]
;
Magda,Tsolaki [34]
;
Margaret A,Pericak-Vance [20]
;
Philippe,Amouyel [243]
;
Julie,Williams [2]
;
Ruth,Frikke-Schmidt [146]
;
Jordi,Clarimon [6]
;
Jean-François,Deleuze [11]
;
Giacomina,Rossi [184]
;
Sudha,Seshadri [5]
;
Ole A,Andreassen [244]
;
Martin,Ingelsson [245]
;
Mikko,Hiltunen ;
Kristel,Sleegers ;
Gerard D,Schellenberg ;
Cornelia M,van Duijn ;
Rebecca,Sims ;
Wiesje M,van der Flier ;
Agustín,Ruiz ;
Alfredo,Ramirez ;
Jean-Charles,Lambert
作者单位：
Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr.
[1]
Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.;Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.;Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
[2]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.;Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands.
[3]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.;German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
[4]
Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.;CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
[5]
Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.;Nuffield Department of Population Health, Oxford University, Oxford, UK.
[6]
Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[7]
Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
[8]
Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
[9]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
[10]
MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
[11]
CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
[12]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.;Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
[13]
Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.;Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
[14]
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
[15]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;Framingham Heart Study, Framingham, MA, USA.
[16]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
[17]
Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
[18]
Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.;LACDR, Leiden, the Netherlands.
[19]
Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
[20]
Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.;Institute of Psychiatry, Psychology & Neuroscience, London, UK.
[21]
Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.;Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain.
[22]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
[23]
Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.;Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.
[24]
Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.;Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain.
[25]
Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
[26]
First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.;Alzheimer Hellas, Thessaloniki, Greece.
[27]
Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
[28]
School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.;Neurology Unit, San Gerardo Hospital, Monza, Italy.
[29]
Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.
[30]
Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy.
[31]
Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.;Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain.
[32]
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.;Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
[33]
NORMENT Centre, University of Oslo, Oslo, Norway.
[34]
EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
[35]
Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
[36]
Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
[37]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;Unit of Neurology, University of Parma and AOU, Parma, Italy.;Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria.
[38]
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.;Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.
[39]
CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
[40]
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
[41]
Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.;Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
[42]
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
[43]
Neuropsychiatry: Epidemiological and Clinical Research, PSNREC, Université de Montpellier, INSERM U1061, Montpellier, France.
[44]
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.;Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
[45]
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.;MAC - Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
[46]
Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
[47]
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.;Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
[48]
Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
[49]
Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
[50]
Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
[51]
Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.;Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
[52]
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.;School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
[53]
Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.;Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
[54]
Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
[55]
Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.;Departamento Ciencias Fisiológicas UAII, Facultad de Medicina, UBA, C.A.B.A., Buenos Aires, Argentina.;Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina.
[56]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
[57]
Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.
[58]
Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.;Wales Centre for Ageing & Dementia Research, Swansea University, Wales, New Zealand.
[59]
Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
[60]
Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.;CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.;UFIEC, Instituto de Salud Carlos III, Madrid, Spain.
[61]
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[62]
INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.;Pole Santé Publique, CHU de Bordeaux, Bordeaux, France.
[63]
Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.
[64]
Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
[65]
Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.;Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain.
[66]
Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
[67]
Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
[68]
Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.
[69]
Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy.
[70]
Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
[71]
Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, the Netherlands.
[72]
Institute for Regenerative Medicine, University of Zürich, Schlieren, Switzerland.
[73]
School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
[74]
Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
[75]
Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
[76]
University of Bari, "A. Moro", Bary, Italy.
[77]
School of Medicine, University of Thessaly, Larissa, Greece.
[78]
Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France.
[79]
Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands.
[80]
Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[81]
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[82]
Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
[83]
UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.
[84]
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
[85]
Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
[86]
Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
[87]
Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.;German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
[88]
Icelandic Heart Association, Kopovagur, Iceland.
[89]
Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.;Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.;Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.;Department of Neurology, UZ Brussel, Brussels, Belgium.
[90]
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.;UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.
[91]
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
[92]
Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
[93]
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.
[94]
Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA.
[95]
Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
[96]
University of Milan, Milan, Italy.
[97]
Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA.;Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
[98]
Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
[99]
Department of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria.
[100]
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
[101]
Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.;German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
[102]
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
[103]
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.;School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
[104]
Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
[105]
Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
[106]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.;Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain.
[107]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.;Hospital Universitario la Paz, Madrid, Spain.
[108]
Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany.
[109]
Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[110]
Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.;University of Milan, Milan, Italy.
[111]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.
[112]
Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
[113]
Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
[114]
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
[115]
Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[116]
CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.
[117]
Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.;Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.
[118]
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
[119]
Institute of Public Health, University of Cambridge, Cambridge, UK.
[120]
Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.;Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.;Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
[121]
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
[122]
Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[123]
Human Genetics, School of Life Sciences, Life Sciences Building, University Park, University of Nottingham, Nottingham, UK.
[124]
AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
[125]
Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
[126]
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
[127]
GRC 21, Alzheimer Precision Medicine Initiative (APMI), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
[128]
Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
[129]
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
[130]
Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.;Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
[131]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
[132]
Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK.
[133]
Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[134]
Department of Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands.
[135]
Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
[136]
Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA.
[137]
Department of Biology, Brigham Young University, Provo, UT, USA.
[138]
Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
[139]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[140]
Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.;Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.;Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.;Research & Development, UnitStockholms Sjukhem, Stockholm, Sweden.
[141]
Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.;Department of Neurology, Kuopio University Hospital, Kuopio, Finland.;Department of Neurosciences, University of Helsinki and Department of Geriatrics, Helsinki University Hospital, Helsinki, Finland.
[142]
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
[143]
Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
[144]
Department of Epidemiology, University of Washington, Seattle, WA, USA.
[145]
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[146]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
[147]
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.;Stockholm Gerontology Research Center, Stockholm, Sweden.
[148]
Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, USA.;Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.
[149]
Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.;Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
[150]
Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.;International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czechia.
[151]
Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA.
[152]
Framingham Heart Study, Framingham, MA, USA.
[153]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain.
[154]
Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.;Department of Neurology, Columbia University, New York, NY, USA.
[155]
School of Health Sciences, Bangor University, Bangor, UK.
[156]
Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
[157]
Unit of Neurology, University of Parma and AOU, Parma, Italy.
[158]
Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain.
[159]
Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.
[160]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
[161]
MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
[162]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
[163]
Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria.
[164]
Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.
[165]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
[166]
Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany.
[167]
Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
[168]
Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.;Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain.
[169]
Laboratory of Brain Aging and Neurodegeneration, FIL-CONICET, Buenos Aires, Argentina.
[170]
Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
[171]
Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
[172]
Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.;Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina.
[173]
Department of Medicine, University of Washington, Seattle, WA, USA.
[174]
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.;IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
[175]
Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
[176]
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
[177]
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
[178]
DIMEC, University of Parma, Parma, Italy.
[179]
Resources and Research Memory Center (MRRC) of Distalz, LicendUniversity of Lille, INSERM, CHU Lille, UMR1172, Lille, France.
[180]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Institut de Biomedicina de València-CSIC CIBERNED, València, Spain.;Unitat Mixta de de Neurología y Genética, Institut d'Investigació Sanitària La Fe, València, Spain.
[181]
US 41-UMS 2014-PLBS, bilille, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France.
[182]
Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.;German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
[183]
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
[184]
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
[185]
CHUV, Old Age Psychiatry, Department of Psychiatry, Lausanne, Switzerland.;Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.;Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland.
[186]
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands.
[187]
German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.;Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité, Charitéplatz 1, Berlin, Germany.
[188]
Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
[189]
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
[190]
Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
[191]
Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.;Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.
[192]
Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands.
[193]
Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.;Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands.;Taub Institute, Columbia University, New York, NY, USA.
[194]
Department of Neurology, Columbia University, New York, NY, USA.;Taub Institute, Columbia University, New York, NY, USA.
[195]
Bioinformatics, College of Life Sciences, Brigham Young University, Provo, UT, USA.
[196]
Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
[197]
Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Wuerzburg, Germany.
[198]
Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.;Institute of Clinical Medicine (K1), The University of Bergen, Bergen, Norway.
[199]
Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain.
[200]
Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
[201]
Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece.
[202]
Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.;Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
[203]
Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain.
[204]
Neurology Department-Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
[205]
Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.;Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.
[206]
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
[207]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
[208]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
[209]
LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
[210]
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
[211]
German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.;Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
[212]
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
[213]
Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy.
[214]
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Hospital Clínico San Carlos, Madrid, Spain.
[215]
Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[216]
Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
[217]
Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.;Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
[218]
German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.;Department of Neurology, University of Bonn, Bonn, Germany.
[219]
Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
[220]
Department of Psychiatry, Namsos Hospital, Namsos, Norway.
[221]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;Department of Neurology, Columbia University, New York, NY, USA.
[222]
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.;Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
[223]
Department of Internal Medicine and Biostatistics, Erasmus MC, Rotterdam, the Netherlands.
[224]
Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
[225]
Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.;Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.;Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
[226]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
[227]
Department of Neurology, ErasmusMC, Rotterdam, the Netherlands.
[228]
Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.;Department of Neurology, ErasmusMC, Rotterdam, the Netherlands.
[229]
Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium.;Neurology Department, University Hospitals Leuven, Leuven, Belgium.
[230]
Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.;Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.
[231]
Department of Neurology and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
[232]
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[233]
Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
[234]
Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.;German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.;Medical Science Department, iBiMED, Aveiro, Portugal.
[235]
Department of Nutrition and Diatetics, Harokopio University, Athens, Greece.
[236]
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
[237]
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.;Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain.
[238]
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.;Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
[239]
Framingham Heart Study, Framingham, MA, USA.;Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Health Service, University of Washington, Seattle, WA, USA.
[240]
Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.;Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.
[241]
MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.;UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.
[242]
Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
[243]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.;German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.;Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.;Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
[244]
Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. Jean-Charles.Lambert@pasteur-lille.fr.
[245]
医学主题词
阿尔茨海默病(Alzheimer Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);tau蛋白质类(tau Proteins)
DOI
10.1038/s41588-022-01024-z
PMID
35379992
发布时间
2026-04-01
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Nature genetics
Nature genetics
412-436页
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