第一作者:
Victor,Nauffal
第一单位:
Division of Cardiovascular Medicine (V.N.), Brigham and Women's Hospital, Boston, MA.;Cardiovascular Disease Initiative (V.N., V.N.M., S.J.J., S.H.C., L.-C.W., J.L.H., P.T.E., S.A.L.), Broad Institute, Cambridge, MA.
作者:
Victor,Nauffal [1]
;
Valerie N,Morrill [2]
;
Sean J,Jurgens [3]
;
Seung Hoan,Choi [4]
;
Amelia W,Hall [5]
;
Lu-Chen,Weng [4]
;
Jennifer L,Halford [4]
;
Christina,Austin-Tse [6]
;
Christopher M,Haggerty [7]
;
Stephanie L,Harris [8]
;
Eugene K,Wong [8]
;
Alvaro,Alonso [9]
;
Dan E,Arking [10]
;
Emelia J,Benjamin [11]
;
Eric,Boerwinkle [12]
;
Yuan-I,Min [13]
;
Adolfo,Correa [13]
;
Brandon K,Fornwalt [7]
;
Susan R,Heckbert [14]
;
National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium [15]
;
Charles,Kooperberg [16]
;
Henry J,Lin [17]
;
Ruth,J F Loos [18]
;
Kenneth M,Rice [19]
;
Namrata,Gupta [20]
;
Thomas W,Blackwell [21]
;
Braxton D,Mitchell [12]
;
Alanna C,Morrison [22]
;
Bruce M,Psaty [23]
;
Wendy S,Post [24]
;
Susan,Redline [6]
;
Heidi L,Rehm [25]
;
Stephen S,Rich [16]
;
Jerome I,Rotter [26]
;
Elsayed Z,Soliman [27]
;
Nona,Sotoodehnia [28]
;
Kathryn L,Lunetta [29]
;
Patrick T,Ellinor [29]
;
Steven A,Lubitz ;
TOPMed Investigators
作者单位:
Division of Cardiovascular Medicine (V.N.), Brigham and Women's Hospital, Boston, MA.;Cardiovascular Disease Initiative (V.N., V.N.M., S.J.J., S.H.C., L.-C.W., J.L.H., P.T.E., S.A.L.), Broad Institute, Cambridge, MA.
[1]
Cardiovascular Disease Initiative (V.N., V.N.M., S.J.J., S.H.C., L.-C.W., J.L.H., P.T.E., S.A.L.), Broad Institute, Cambridge, MA.
[2]
Cardiovascular Disease Initiative (V.N., V.N.M., S.J.J., S.H.C., L.-C.W., J.L.H., P.T.E., S.A.L.), Broad Institute, Cambridge, MA.;Department of Experimental Cardiology, Amsterdam University Medical Centers, The Netherlands (S.J.J.).;Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge (N.G., S.J.J., S.H.C., L.C.W., J.L.H., C.A.T., H.L.R., P.T.E., S.A.L.).
[3]
Cardiovascular Disease Initiative (V.N., V.N.M., S.J.J., S.H.C., L.-C.W., J.L.H., P.T.E., S.A.L.), Broad Institute, Cambridge, MA.;Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge (N.G., S.J.J., S.H.C., L.C.W., J.L.H., C.A.T., H.L.R., P.T.E., S.A.L.).
[4]
Gene Regulation Observatory (A.W.H.), Broad Institute, Cambridge, MA.
[5]
Center for Genomic Medicine (C.A.-T., H.L.R.), Massachusetts General Hospital, Boston.;Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge (N.G., S.J.J., S.H.C., L.C.W., J.L.H., C.A.T., H.L.R., P.T.E., S.A.L.).
[6]
Department of Translational Data Science and Informatics, Geisinger, Danville, PA (C.M.H., B.K.F.).
[7]
Cardiovascular Genetics Program (S.L.H., E.K.W.), Massachusetts General Hospital, Boston.
[8]
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.).
[9]
McKusick-Nathans Institute, Department of Genetic Medicine (D.E.A.), Johns Hopkins University School of Medicine, Baltimore, MD.
[10]
Boston University School of Public Health, MA (E.J.B., K.L.L.).;Boston University School of Medicine, MA (E.J.B.).
[11]
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (E.B., A.C.M.).
[12]
Department of Medicine, University of Mississippi Medical Center, Jackson (Y.-I.M., A.C.).
[13]
Cardiovascular Health Research Unit and Department of Epidemiology (S.R.H.).
[14]
Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA (C.K.).
[15]
Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-University of California-Los Angeles Medical Center, Torrance (H.J.L., J.I.R.).
[16]
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York (R.J.F.L.).
[17]
Department of Biostatistics (K.M.R.).
[18]
Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge (N.G., S.J.J., S.H.C., L.C.W., J.L.H., C.A.T., H.L.R., P.T.E., S.A.L.).
[19]
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor (T.W.B.).
[20]
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore (B.D.M.).
[21]
Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Systems and Population Health, University of Washington, Seattle, WA (B.M.P.).
[22]
Division of Cardiology, Department of Medicine (W.S.P.), Johns Hopkins University School of Medicine, Baltimore, MD.
[23]
Harvard Medical School (S.R.), Brigham and Women's Hospital, Boston, MA.
[24]
Center for Public Health Genomics and Department of Public Health Sciences, University of Virginia, Charlottesville (S.S.R.).
[25]
Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston-Salem, NC (E.Z.S.).
[26]
Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, Cardiology, University of Washington, Seattle, WA (N.S.).
[27]
Boston University School of Public Health, MA (E.J.B., K.L.L.).
[28]
Cardiovascular Disease Initiative (V.N., V.N.M., S.J.J., S.H.C., L.-C.W., J.L.H., P.T.E., S.A.L.), Broad Institute, Cambridge, MA.;Cardiac Arrhythmia Service and Cardiovascular Research Center (P.T.E., S.A.L.), Massachusetts General Hospital, Boston.;Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge (N.G., S.J.J., S.H.C., L.C.W., J.L.H., C.A.T., H.L.R., P.T.E., S.A.L.).
[29]
主题词
心电描记术(Electrocardiography);全基因组关联研究(Genome-Wide Association Study);杂合子(Heterozygote);人类(Humans);QT延长综合征(Long QT Syndrome);多因子遗传(Multifactorial Inheritance)
DOI
10.1161/CIRCULATIONAHA.121.057261
PMID
35389749
发布时间
2024-06-07
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Circulation
Circulation
1524-1533页
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