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Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.

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第一作者： Alexandra,Papp

第一单位： MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.

作者： Alexandra,Papp ^[1] ; Krisztián,Papp ^[2] ; Barbara,Uzonyi ^[3] ; Marcell,Cserhalmi ^[1] ; Ádám I,Csincsi ^[1] ; Zsóka,Szabó ^[1] ; Zsófia,Bánlaki ^[1] ; David,Ermert ^[4] ; Zoltán,Prohászka ^[5] ; Anna,Erdei ^[6] ; Viviana P,Ferreira ^[7] ; Anna M,Blom ^[4] ; Mihály,Józsi ^[8]

作者单位： MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary. ^[1] MTA-ELTE Immunology Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary. ^[2] MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.;MTA-ELTE Immunology Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary. ^[3] Department of Translational Medicine, Lund University, Malmo, Sweden. ^[4] Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.;Research Group for Immunology and Haematology, Semmelweis University-Eötvös Loránd Research Network (Office for Supported Research Groups), Budapest, Hungary. ^[5] MTA-ELTE Immunology Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.;Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary. ^[6] Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, OH, United States. ^[7] MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.;Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary. ^[8]

关键词 Bruch’s membrane (BM)complement regulation extracellular matrix (ECM)factor H (FH)factor H-related protein (FHR)glomerular basement membrane (GBM)kidney disease laminin