Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.

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第一作者： Leilei,Zhong

第一单位： Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

作者： Leilei,Zhong ^[1] ; Lutian,Yao ^[1] ; Nicholas,Holdreith ^[2] ; Wei,Yu ^[3] ; Tao,Gui ^[4] ; Zhen,Miao ^[5] ; Yehuda,Elkaim ^[1] ; Mingyao,Li ^[6] ; Yanqing,Gong ^[1] ; Maurizio,Pacifici ^[7] ; Amit,Maity ^[1] ; Theresa M,Busch ^[7] ; Kyu Sang,Joeng ^[8] ; Keith,Cengel ^[2] ; Patrick,Seale ^[9] ; Wei,Tong ^[9] ; Ling,Qin ^[1]

作者单位： Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[1] Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. ^[2] Department of Orthopaedics, The First Hospital of China Medical University, Shenyang, China. ^[3] Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. ^[4] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[5] Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ^[6] Department of Biostatistics, Epidemiology and Informatics. ^[7] Division of Translational Medicine and Human Genetics. ^[8] Department of Radiation Oncology, and. ^[9] Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[10]

关键词 Bioinformatics Bone Biology Bone marrow Radiation therapy Vascular Biology

主题词成脂分化(Adipogenesis);骨髓(Bone Marrow);骨髓细胞(Bone Marrow Cells);细胞分化(Cell Differentiation);肌成纤维细胞(Myofibroblasts)

DOI 10.1172/jci.insight.150323

PMID 35393948

发布时间 2022-07-16

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2022年7卷7期

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Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.

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Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.

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