换一批Research on the mechanism of berberine in the treatment of COVID-19 pneumonia pulmonary fibrosis using network pharmacology and molecular docking.
第一作者：
Junfeng,Cao
第一单位：
Clinical Laboratory Medicine, Chengdu Medical College, Chengdu, China.
作者：
关键词
ARDS, acute respiratory distress syndromeBP, biological processBerberineCC, cellular componentCCL2, chemokine ligand2COVID-19COVID-19 pneumoniaCOVID-19, corona virus disease 2019ECM, extracellular matrixEMT, epithelial-mesenchymal cell transformationFOXM1, forkhead box M1Fsp1, fibroblast-specific protein 1GO, gene ontologyHIF-1, hypoxia inducible factorIBD, inflammatory bowel diseaseIL-12, interleukin 12IL-6, interleukin 6JAK, Janus kinaseKEGG, Kyoto encyclopedia of genes and genomesLR-MSCs, mesenchymal stem cellsMF, molecular functionMMP14, matrix metalloproteinase 14MMP7, matrix metalloproteinase 7Molecular dockingNF-κB, nuclear transcription factorNOS, nitric oxide synthaseNetwork pharmacologyOTUB1, deubiquitinasePAI-1, plasminogen activator inhibitor 1PPI, protein-protein interactionPulmonary fibrosisSTAT3, transcription activatorTGF-β, transforming growth factor-βTNF-α, tumor necrosis factor-αsIL-6R, interleukin 6 receptorα-SMA, α-smooth muscle actin
DOI
10.1016/j.phyplu.2022.100252
PMID
35403089
发布时间
2022-07-16
- 浏览4
Phytomedicine plus
2022年2卷2期
100252页
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