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Potential Therapeutic Target Protein Tyrosine Phosphatase-1B for Modulation of Insulin Resistance with Polyphenols and Its Quantitative Structure-Activity Relationship.

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第一作者： Prangya,Rath

第一单位： Amity Institute of Environmental Sciences, Amity University, Noida 201303, India.

作者： Prangya,Rath ^[1] ; Anuj,Ranjan ^[2] ; Arabinda,Ghosh ^[3] ; Abhishek,Chauhan ^[4] ; Manisha,Gurnani ^[1] ; Hardeep Singh,Tuli ^[5] ; Hamza,Habeeballah ^[6] ; Mustfa F,Alkhanani ^[7] ; Shafiul,Haque ^[8] ; Kuldeep,Dhama ^[9] ; Naval Kumar,Verma ^[10] ; Tanu,Jindal ^[4]

作者单位： Amity Institute of Environmental Sciences, Amity University, Noida 201303, India. ^[1] Academy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia. ^[2] Microbiology Division, Department of Botany, Gauhati University, Guwahati 781014, India. ^[3] Amity Institute of Environmental Toxicology Safety and Management, Amity University, Noida 201303, India. ^[4] Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, India. ^[5] Faculty of Applied Medical Sciences, King Abdulaziz University, Rabigh Branch, Rabigh 25732, Saudi Arabia. ^[6] Emergency Service Department, College of Applied Sciences, AlMaarefa University, Riyadh 11597, Saudi Arabia. ^[7] Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.;Faculty of Medicine, Bursa Uludağ University Görükle Campus, Nilüfer 16059, Turkey. ^[8] Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, India. ^[9] Homeopathy, Ministry of Ayush, Ayush Bhawan, B Block, GPO Complex INA, New Delhi 110023, India. ^[10]

关键词 QSAR catalytic active site diabetes docking insulin resistance molecular dynamic simulation polyphenols

医学主题词糖尿病, 2型(Diabetes Mellitus, Type 2);酶抑制剂(Enzyme Inhibitors);人类(Humans);胰岛素抗药性(Insulin Resistance);蛋白质酪氨酸磷酸酶, 非受体1型(Protein Tyrosine Phosphatase, Non-Receptor Type 1);量化构效关系(Quantitative Structure-Activity Relationship);构效关系(Structure-Activity Relationship)

DOI 10.3390/molecules27072212

PMID 35408611

发布时间 2022-04-23

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