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Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs.

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第一作者： Joanna,Hummer

第一单位： Joanneum Research Forschungsgesellschaft mbH, Health-Institute for Biomedicine and Health Sciences, Neue Stiftingtalstraße 2, 8010 Graz, Austria.

作者： Joanna,Hummer ^[1] ; Thomas,Birngruber ^[1] ; Frank,Sinner ^[1] ; Leanne,Page ^[2] ; Frank,Toner ^[2] ; Clive S,Roper ^[3] ; David J,Moore ^[4] ; Mark B,Baker ^[5] ; Mila,Boncheva Bettex ^[6]

作者单位： Joanneum Research Forschungsgesellschaft mbH, Health-Institute for Biomedicine and Health Sciences, Neue Stiftingtalstraße 2, 8010 Graz, Austria. ^[1] Charles River Laboratories, Tranent, Edinburgh EH33 2NE, UK. ^[2] Roper Toxicology Consulting Limited, 6 St Colme Street, Edinburgh EH3 6AD, UK. ^[3] GSK Consumer Healthcare, 184 Liberty Corner Rd, Warren, NJ 07059, USA. ^[4] GSK Consumer Healthcare SARL, Route de l'Etraz 2, Case postale 1279, 1260 Nyon 1, Switzerland. ^[5] GSK Consumer Healthcare SARL, Route de l'Etraz 2, Case postale 1279, 1260 Nyon 1, Switzerland. Electronic address: mila.x.boncheva-bettex@gsk.com. ^[6]

关键词 Formulation optimization Franz diffusion cell In vitro Open flow microperfusion Passive diffusion Topical diclofenac

医学主题词投药, 皮肤(Administration, Cutaneous);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);二氯酚酸(Diclofenac);药用制剂(Pharmaceutical Preparations);皮肤(Skin);皮肤吸收(Skin Absorption)

DOI 10.1016/j.ijpharm.2022.121737

PMID 35413396

发布时间 2022-05-17

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