Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzyme.

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作者： Jimin,Wang ^[1] ; Erin,Skeens ^[2] ; Pablo R,Arantes ^[3] ; Federica,Maschietto ^[4] ; Brandon,Allen ^[4] ; Gregory W,Kyro ^[4] ; George P,Lisi ^[2] ; Giulia,Palermo ^[3] ; Victor S,Batista ^[4]

作者单位： Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8114, United States. ^[1] Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, United States. ^[2] Department of Bioengineering and Department of Chemistry, University of California Riverside, Riverside, California 92521-9800, United States. ^[3] Department of Chemistry, Yale University, New Haven, Connecticut 06511-8499, United States. ^[4]

主题词 DNA(DNA);内切核酸酶类(Endonucleases)

DOI 10.1021/acs.biochem.2c00127

PMID 35420793

发布时间 2024-11-12

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Biochemistry

2022年61卷9期

785-794页

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Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzyme.

Biochemistry

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Biochemistry

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Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzyme.

Biochemistry

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Biochemistry

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