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首页> Neurochemistry international> DJ-1 activates the Atg5-Atg12-Atg16L1 complex via Sirt1 to influence microglial polarization and alleviate cerebral ischemia/reperfusion-induced inflammatory injury.

DJ-1 activates the Atg5-Atg12-Atg16L1 complex via Sirt1 to influence microglial polarization and alleviate cerebral ischemia/reperfusion-induced inflammatory injury.

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作者： Na,Zhao ^[1] ; Yumei,Li ^[2] ; Chenglong,Wang ^[3] ; Ying,Xue ^[2] ; Li,Peng ^[2] ; Tingting,Wang ^[2] ; Yong,Zhao ^[2] ; Ge,Xu ^[4] ; Shanshan,Yu ^[5]

作者单位： Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China; Chengdu Second People's Hospital, 610000, Chengdu, PR China. ^[1] Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China. ^[2] Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China; Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, 400021, Chongqing, PR China. ^[3] Institute of Life Sciences, Chongqing Medical University, 400016, Chongqing, PR China. ^[4] Department of Pathology, College of Basic Medicine, Chongqing Medical University, 400016, Chongqing, PR China. Electronic address: yushanshan2014@cqmu.edu.cn. ^[5]

关键词 Atg5-Atg12-Atg16L1 Autophagy Cerebral I/R injury DJ-1 Microglial polarization Sirt1

主题词消炎药(Anti-Inflammatory Agents);脑缺血(Brain Ischemia);细胞极性(Cell Polarity);人类(Humans);小神经胶质细胞(Microglia);再灌注(Reperfusion);再灌注损伤(Reperfusion Injury);抗衰老酶1(Sirtuin 1)

DOI 10.1016/j.neuint.2022.105341

PMID 35429577

发布时间 2022-06-23

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Neurochemistry international

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