xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade.
作者:
主题词
氨基酸转运系统y+(Amino Acid Transport System y+);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);细胞转化, 肿瘤(Cell Transformation, Neoplastic);结直肠肿瘤(Colorectal Neoplasms);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);癌基因(Oncogenes);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);增量调节(Up-Regulation)
DOI
10.1038/s41419-022-04827-4
PMID
35440604
发布时间
2022-12-11
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