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Development of a Spray-Dried Formulation of Peptide-DNA Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design.

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第一作者： Miftakul,Munir

第一单位： School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.;Research and Technology Center for Radioisotope and Radiopharmaceutical, National Research and Innovation Agency, South Tangerang, Indonesia.

作者： Miftakul,Munir ^[1] ; Vicky L,Kett ^[2] ; Nicholas J,Dunne ^[3] ; Helen O,McCarthy ^[4]

作者单位： School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.;Research and Technology Center for Radioisotope and Radiopharmaceutical, National Research and Innovation Agency, South Tangerang, Indonesia. ^[1] School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. ^[2] School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.;Centre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin 9, Ireland.;Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.;Advanced Manufacturing Research Centre (I-Form), School of Mechanical and Manufacturing Engineering, Dublin City University, Glasnevin, Dublin 9, Ireland.;Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin 2, Ireland.;Advanced Processing Technology Research Centre, Dublin City University, Dublin 9, Ireland.;Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.;School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin 9, Ireland. ^[3] School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. h.mccarthy@qub.ac.uk.;School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. h.mccarthy@qub.ac.uk. ^[4]

关键词 cell-penetrating peptide dry powder formulation gene delivery pulmonary delivery spray drying