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Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression.

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第一作者: Zhiming,Li
第一单位: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.;BGI-Shenzhen, Shenzhen, 518083, China.;China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.;Shenzhen Key Laboratory of Neurogenomics, BGI-Shenzhen, Shenzhen, 518083, China.
作者: Zhiming,Li [1] ; Jianbo,Lai [2] ; Peifen,Zhang [3] ; Jiahong,Ding [4] ; Jiajun,Jiang [3] ; Chuanfa,Liu [5] ; Huimin,Huang [6] ; Hefu,Zhen [4] ; Caixi,Xi [3] ; Yuzhe,Sun [4] ; Lingling,Wu [3] ; Lifang,Wang [4] ; Xingle,Gao [3] ; Yan,Li [4] ; Yaoyang,Fu [3] ; Zhuye,Jie [7] ; Shenghui,Li [8] ; Danhua,Zhang [3] ; Yiqing,Chen [3] ; Yiyi,Zhu [6] ; Shaojia,Lu [2] ; Jing,Lu [2] ; Dandan,Wang [2] ; Hetong,Zhou [2] ; Xiuxia,Yuan [9] ; Xue,Li [9] ; Lijuan,Pang [9] ; Manli,Huang [2] ; Huanming,Yang [7] ; Wenwei,Zhang [4] ; Susanne,Brix [10] ; Karsten,Kristiansen [11] ; Xueqin,Song [12] ; Chao,Nie [13] ; Shaohua,Hu [14]
作者单位: Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.;BGI-Shenzhen, Shenzhen, 518083, China.;China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.;Shenzhen Key Laboratory of Neurogenomics, BGI-Shenzhen, Shenzhen, 518083, China. [1] Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.;The Key Laboratory of Mental Disorder's Management in Zhejiang Province, Hangzhou, 310003, China.;Brain Research Institute of Zhejiang University, Hangzhou, 310003, China.;Zhejiang Engineering Center for Mathematical Mental Health, Hangzhou, 310003, China. [2] Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. [3] BGI-Shenzhen, Shenzhen, 518083, China.;China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.;Shenzhen Key Laboratory of Neurogenomics, BGI-Shenzhen, Shenzhen, 518083, China. [4] BGI-Shenzhen, Shenzhen, 518083, China.;China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China.;College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China. [5] Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.;Wenzhou Medical University, Wenzhou, 325035, China. [6] BGI-Shenzhen, Shenzhen, 518083, China.;China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China. [7] Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China. [8] Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.;Biological Psychiatry International Joint Laboratory of Henan, Zhengzhou University, Zhengzhou, 450052, China. [9] Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs, Lyngby, Denmark. sbp@bio.dtu.dk.;Qingdao-Europe Advanced Institute for Life Sciences, Qingdao, Shandong, 266555, China. sbp@bio.dtu.dk. [10] BGI-Shenzhen, Shenzhen, 518083, China. kk@bio.ku.dk.;Qingdao-Europe Advanced Institute for Life Sciences, Qingdao, Shandong, 266555, China. kk@bio.ku.dk.;Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, DK-2100, København, Denmark. kk@bio.ku.dk. [11] Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. fccsongxq@zzu.edu.cn.;Biological Psychiatry International Joint Laboratory of Henan, Zhengzhou University, Zhengzhou, 450052, China. fccsongxq@zzu.edu.cn. [12] BGI-Shenzhen, Shenzhen, 518083, China. niechao@genomics.cn.;China National GeneBank, BGI-Shenzhen, Shenzhen, 518120, China. niechao@genomics.cn.;Shenzhen Key Laboratory of Neurogenomics, BGI-Shenzhen, Shenzhen, 518083, China. niechao@genomics.cn. [13] Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. dorhushaohua@zju.edu.cn.;The Key Laboratory of Mental Disorder's Management in Zhejiang Province, Hangzhou, 310003, China. dorhushaohua@zju.edu.cn.;Brain Research Institute of Zhejiang University, Hangzhou, 310003, China. dorhushaohua@zju.edu.cn.;Zhejiang Engineering Center for Mathematical Mental Health, Hangzhou, 310003, China. dorhushaohua@zju.edu.cn.;Department of Neurobiology, NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brian Medicine, and MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University School of Medicine, Hangzhou, 310058, China. dorhushaohua@zju.edu.cn. [14]
DOI 10.1038/s41380-022-01569-9
PMID 35444255
发布时间 2023-04-07
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