Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity.

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作者： Yunseok,Heo ^[1] ; Eojin,Yoon ^[2] ; Ye-Eun,Jeon ^[1] ; Ji-Hye,Yun ^[1] ; Naito,Ishimoto ^[3] ; Hyeonuk,Woo ^[4] ; Sam-Yong,Park ^[5] ; Ji-Joon,Song ^[4] ; Weontae,Lee ^[2]

作者单位： Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea. ^[1] Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. ^[2] PCG-Biotech, Ltd., 508 KBIZ DMC Tower, Sangam-Ro, Seoul, Republic of Korea. ^[3] Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan. ^[4] Department of Chemistry, Seoul National University, Seoul, Republic of Korea. ^[5]

关键词 G-protein human ligand membrane protein molecular biophysics structural biology

主题词冷冻电子显微镜检查(Cryoelectron Microscopy);人类(Humans);配体(Ligands);受体, 生长抑素(Receptors, Somatostatin);生长抑素(Somatostatin)

DOI 10.7554/eLife.76823

PMID 35446253

发布时间 2022-07-16

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