Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids.

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第一作者： Anand K,Muthusamy

第一单位： Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91106, United States.;Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91106, United States.

作者： Anand K,Muthusamy ^[1] ; Charlene H,Kim ^[2] ; Scott C,Virgil ^[3] ; Hailey J,Knox ^[3] ; Jonathan S,Marvin ^[4] ; Aaron L,Nichols ^[2] ; Bruce N,Cohen ^[2] ; Dennis A,Dougherty ^[3] ; Loren L,Looger ^[5] ; Henry A,Lester ^[2]

作者单位： Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91106, United States.;Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91106, United States. ^[1] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91106, United States. ^[2] Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91106, United States. ^[3] Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia 20147, United States. ^[4] Howard Hughes Medical Institute, University of California, San Diego, San Diego, California 92093, United States. ^[5]