首页> JCI insight> Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases.

Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases.

导出 LinkOut

翻译打印收藏纠错

第一作者： Yong,Li

第一单位： Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, and.

作者： Yong,Li ^[1] ; Yurong,Cheng ^[2] ; Francesco,Consolato ^[3] ; Guglielmo,Schiano ^[4] ; Michael R,Chong ^[5] ; Maik,Pietzner ^[6] ; Ngoc Quynh H,Nguyen ^[7] ; Nora,Scherer ^[8] ; Mary L,Biggs ^[9] ; Marcus E,Kleber ^[10] ; Stefan,Haug ^[1] ; Burulça,Göçmen ^[1] ; Marie,Pigeyre ^[11] ; Peggy,Sekula ^[1] ; Inga,Steinbrenner ^[1] ; Pascal,Schlosser ^[12] ; Christina B,Joseph ^[13] ; Jennifer A,Brody ^[14] ; Morgan E,Grams ^[15] ; Caroline,Hayward ^[13] ; Ulla T,Schultheiss ^[16] ; Bernhard K,Krämer ^[17] ; Florian,Kronenberg ^[18] ; Annette,Peters ^[19] ; Jochen,Seissler ^[20] ; Dominik,Steubl ^[21] ; Cornelia,Then ^[20] ; Matthias,Wuttke ^[16] ; Winfried,März ^[22] ; Kai-Uwe,Eckardt ^[23] ; Christian,Gieger ^[24] ; Eric,Boerwinkle ^[25] ; Bruce M,Psaty ^[26] ; Josef,Coresh ^[27] ; Peter J,Oefner ^[28] ; Guillaume,Pare ^[29] ; Claudia,Langenberg ^[6] ; Jürgen E,Scherberich ^[30] ; Bing,Yu ^[7] ; Shreeram,Akilesh ^[31] ; Olivier,Devuyst ^[4] ; Luca,Rampoldi ^[3] ; Anna,Köttgen ^[32]

作者单位： Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, and. ^[1] Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, and.;Faculty of Biology, University of Freiburg, Freiburg, Germany. ^[2] Molecular Genetics of Renal Disorders group, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy. ^[3] Institute of Physiology, University of Zurich, Zurich, Switzerland. ^[4] Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.;Department of Biochemistry and Biomedical Sciences and.;Department of Pathology and Molecular Medicine, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. ^[5] Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.;Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. ^[6] Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA. ^[7] Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, and.;Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany. ^[8] Cardiovascular Health Research Unit, Department of Medicine, and.;Department of Biostatistics, University of Washington, Seattle, Washington, USA. ^[9] SYNLAB MVZ Humangenetik Mannheim GmbH, Mannheim, Germany.;Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. ^[10] Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.;Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. ^[11] Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, and.;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. ^[12] MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom. ^[13] Cardiovascular Health Research Unit, Department of Medicine, and. ^[14] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.;Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. ^[15] Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, and.;Department of Medicine IV: Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany. ^[16] Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. ^[17] Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. ^[18] Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.;Chair of Epidemiology, Institute for Medical Information Processing, Biometry, and Epidemiology, Faculty of Medicine, Ludwig-Maximilians-Universität (LMU), Munich, Germany. ^[19] Medical Clinic and Policlinic IV, Hospital of the University of Munich, LMU Munich, Munich, Germany. ^[20] Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.;Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.;Boehringer Ingelheim International GmbH, Ingelheim, Germany. ^[21] Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.;Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.;SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Augsburg and Mannheim, Germany. ^[22] Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.;Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[23] Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.;Research Unit of Molecular Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.;German Center for Diabetes Research (DZD), Partner Munich, Neuherberg, Germany. ^[24] Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.;Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA. ^[25] Cardiovascular Health Research Unit, Department of Medicine, and.;Department of Epidemiology and.;Department of Health Systems and Population Health, School of Public Health, University of Washington, Seattle, Washington, USA. ^[26] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. ^[27] Institute of Functional Genomics, University of Regensburg, Regensburg, Germany. ^[28] Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.;Department of Pathology and Molecular Medicine, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. ^[29] Munich Clinic Harlaching, LMU Munich, Munich, Germany. ^[30] Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA. ^[31] Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, and.;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.;Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany. ^[32]

关键词 Chronic kidney disease Genetics Nephrology Population genetics

医学主题词血压(Blood Pressure);全基因组关联研究(Genome-Wide Association Study);人类(Humans);高血压(Hypertension);肾功能不全, 慢性(Renal Insufficiency, Chronic);尿调节素(Uromodulin)

DOI 10.1172/jci.insight.157035

PMID 35446786

发布时间 2025-05-30

基金项目