A gain-of-function mutation in the acid-sensing ion channel 2a induces marked cerebellar maldevelopment in rats.

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作者： Yasuhiro,Shibata ^[1] ; Natsuko,Kumamoto ^[1] ; Eisuke,Sakuma ^[2] ; Yusuke,Ishida ^[3] ; Takashi,Ueda ^[1] ; Shoichi,Shimada ^[4] ; Shinya,Ugawa ^[5]

作者单位： Department of Anatomy and Neuroscience, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan. ^[1] Department of Integrative Anatomy, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan. ^[2] Division of Histology and Anatomy, Department of Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan. ^[3] Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, 541-8567, Japan. ^[4] Department of Anatomy and Neuroscience, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan. Electronic address: ugawa@med.nagoya-cu.ac.jp. ^[5]

关键词 ASIC2a Ataxia Brain atrophy Neurodegeneration Rotarod test Transgenic rat

主题词动物(Animals);小脑(Cerebellum);突变(Mutation);大鼠(Rats)

DOI 10.1016/j.bbrc.2022.04.030

PMID 35447498

发布时间 2022-05-31

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