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Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity.

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第一作者： Wael,Zeinyeh

第一单位： Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France.

作者： Wael,Zeinyeh ^[1] ; Yannick J,Esvan ^[1] ; Béatrice,Josselin ^[2] ; Mathilde,Defois ^[1] ; Blandine,Baratte ^[2] ; Stefan,Knapp ^[3] ; Apirat,Chaikuad ^[3] ; Fabrice,Anizon ^[1] ; Francis,Giraud ^[4] ; Sandrine,Ruchaud ^[5] ; Pascale,Moreau ^[6]

作者单位： Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France. ^[1] Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France; Sorbonne Université, CNRS, FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique de Roscoff, 29680, Roscoff, France. ^[2] Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium (SGC), Max-von-Laue-Str. 15, 60438, Frankfurt am Main, Germany. ^[3] Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France. Electronic address: francis.giraud@uca.fr. ^[4] Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France. Electronic address: sandrine.ruchaud@sb-roscoff.fr. ^[5] Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000, Clermont-Ferrand, France. Electronic address: pascale.moreau@uca.fr. ^[6]

关键词 Haspin Kinase inhibition Pyridoquinazolines

医学主题词人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);蛋白激酶抑制剂(Protein Kinase Inhibitors);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2022.114369

PMID 35447555

发布时间 2022-05-17

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