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Modelling the Compaction Step of a Platform Direct Compression Process.

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第一作者： Raghu V G,Peddapatla

第一单位： SSPC Pharmaceutical Research Centre, School of Pharmacy, University College Cork, T12 K8AF Cork, Ireland.;Alkermes Pharma Ireland Limited, N37 EA09 Athlone, Ireland.

作者： Raghu V G,Peddapatla ^[1] ; Conor,Slevin ^[2] ; Gerard,Sheridan ^[2] ; Caoimhe,Beirne ^[3] ; Shrikant,Swaminathan ^[4] ; Ivan,Browning ^[3] ; Clare,O'Reilly ^[3] ; Zelalem A,Worku ^[3] ; David,Egan ^[5] ; Stephen,Sheehan ^[3] ; Abina M,Crean ^[6]

作者单位： SSPC Pharmaceutical Research Centre, School of Pharmacy, University College Cork, T12 K8AF Cork, Ireland.;Alkermes Pharma Ireland Limited, N37 EA09 Athlone, Ireland. ^[1] Alkermes Pharma Ireland Limited, N37 EA09 Athlone, Ireland.;Pharmaceutical Manufacturing Technology Centre (PMTC), Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland. ^[2] Alkermes Pharma Ireland Limited, N37 EA09 Athlone, Ireland. ^[3] Alkermes Inc., Waltham, MA 02451, USA. ^[4] Pharmaceutical Manufacturing Technology Centre (PMTC), Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland. ^[5] SSPC Pharmaceutical Research Centre, School of Pharmacy, University College Cork, T12 K8AF Cork, Ireland. ^[6]

关键词 compaction direct compression drug development formulation development platform process porosity process model process optimisation tensile strength

DOI 10.3390/pharmaceutics14040695

PMID 35456529

发布时间 2022-07-16

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