Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function.

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作者： Fumie,Mitani ^[1] ; Jianyu,Lin ^[2] ; Tatsuya,Sakamoto ^[3] ; Ryo,Uehara ^[1] ; Tomoya,Hikita ^[4] ; Takuya,Yoshida ^[1] ; Andi,Setiawan ^[1] ; Masayoshi,Arai ^[5] ; Chitose,Oneyama ^[6]

作者单位： Division of Cancer Cell Regulation, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan. ^[1] Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan. ^[2] Laboratory of Natural Products for Drug Discovery, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan. ^[3] Department of Target and Drug Discovery, Graduate School of Medicine, Nagoya University, Showa-ku, Nagoya, Japan. ^[4] Laboratory of Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan. ^[5] Department of Chemistry, Faculty of Mathematics and Natural Sciences, Lampung University, Bandar Lampung, Indonesia. ^[6] Laboratory of Natural Products for Drug Discovery, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan. araim@phs.osaka-u.ac.jp. ^[7] Division of Cancer Cell Regulation, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan. coneyama@aichi-cc.jp. ^[8] Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan. coneyama@aichi-cc.jp. ^[9] Department of Target and Drug Discovery, Graduate School of Medicine, Nagoya University, Showa-ku, Nagoya, Japan. coneyama@aichi-cc.jp. ^[10] JST, PRESTO, Nagoya, Japan. coneyama@aichi-cc.jp. ^[11]

主题词 AMP活化蛋白激酶类(AMP-Activated Protein Kinases);溶酶体(Lysosomes);吡喃酮类(Pyrones);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)

DOI 10.1038/s41598-022-10692-0

PMID 35461323

发布时间 2022-07-16

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