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Selumetinib in children with neurofibromatosis type 1 and asymptomatic inoperable plexiform neurofibroma at risk for developing tumor-related morbidity.

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第一作者： Andrea M,Gross

第一单位： Pediatric Oncology Branch, Center for Cancer research, National Cancer Institute, Bethesda, Maryland, USA.

作者： Andrea M,Gross ^[1] ; Brittany,Glassberg ^[1] ; Pamela L,Wolters ^[1] ; Eva,Dombi ^[1] ; Andrea,Baldwin ^[1] ; Michael J,Fisher ^[2] ; AeRang,Kim ^[3] ; Miriam,Bornhorst ^[3] ; Brian D,Weiss ^[4] ; Jaishri O,Blakeley ^[5] ; Patricia,Whitcomb ^[1] ; Scott M,Paul ^[6] ; Seth M,Steinberg ^[7] ; David J,Venzon ^[7] ; Staci,Martin ^[1] ; Amanda,Carbonell ^[1] ; Kara,Heisey ^[1] ; Janet,Therrien ^[1] ; Oxana,Kapustina ^[1] ; Anne,Dufek ^[1] ; Joanne,Derdak ^[1] ; Malcolm A,Smith ^[8] ; Brigitte C,Widemann ^[1]

作者单位： Pediatric Oncology Branch, Center for Cancer research, National Cancer Institute, Bethesda, Maryland, USA. ^[1] Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. ^[2] Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC, USA. ^[3] Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. ^[4] Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA. ^[5] Rehabilitation Medicine Department, NIH Clinical Center, Baltimore, Maryland, USA. ^[6] Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Baltimore, Maryland, USA. ^[7] Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA (M.A.S.). ^[8]

关键词 MEK inhibitor neurofibromatosis type 1 patient-reported outcome measures plexiform neurofibroma selumetinib

医学主题词儿童(Child);人类(Humans);神经纤维瘤, 丛状(Neurofibroma, Plexiform);神经纤维瘤病1型(Neurofibromatosis 1);苯咪唑类(Benzimidazoles);年患病率(Morbidity);疼痛(Pain)

DOI 10.1093/neuonc/noac109

PMID 35467749

发布时间 2023-04-26

基金项目

U54 CA196519/CA/NCI NIH HHS/United States

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准确一般字义偏差语意偏离译文作用小提交