Combined multi-omics and network pharmacology approach reveals the role of Tripterygium Wilfordii Hook F in treating HIV immunological non-responders.

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作者： Xiaosheng,Liu ^[1] ; Ling,Lin ^[2] ; Tingxia,Lv ^[2] ; Lianfeng,Lu ^[3] ; Xiaodi,Li ^[3] ; Yang,Han ^[3] ; Zhifeng,Qiu ^[3] ; Xiaoxia,Li ^[3] ; Yanling,Li ^[3] ; Xiaojing,Song ^[3] ; Wei,Cao ^[3] ; Taisheng,Li ^[4]

作者单位： Tsinghua-Peking Center for Life Sciences, Beijing, China; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. ^[1] Department of Infectious Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China. ^[2] Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. ^[3] Tsinghua-Peking Center for Life Sciences, Beijing, China; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address: litsh@263.net. ^[4]

关键词 CD4 recovery Immunological non-responder Interferon STAT1 Tripterygium Wilfordii Hook F Triptolide

主题词中草药(Drugs, Chinese Herbal);HIV感染(HIV Infections);人类(Humans);白细胞, 单核(Leukocytes, Mononuclear);蛋白质组学(Proteomics);雷公藤属(Tripterygium)

DOI 10.1016/j.phymed.2022.154103

PMID 35468451

发布时间 2022-05-18

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