SARS-CoV-2-specific immune responses in elderly and immunosuppressed participants and patients with hematologic disease or checkpoint inhibition in solid tumors: study protocol of the prospective, observational CoCo immune study.

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第一作者： Alexandra,Dopfer-Jablonka

第一单位： Department for Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.;German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany.

作者： Alexandra,Dopfer-Jablonka ^[1] ; Sandra,Steffens ^[2] ; Frank,Müller ^[3] ; Marie,Mikuteit ^[2] ; Jacqueline,Niewolik ^[2] ; Anne,Cossmann ^[2] ; Metodi V,Stankov ^[2] ; Georg M N,Behrens ^[4] ; Eva,Hummers ^[3] ; Gloria,Heesen ^[3] ; Dominik,Schröder ^[5] ; Sascha,Roder ^[3] ; Frank,Klawonn ^[6] ; Kai,Vahldiek ^[7] ; Justin,Hasenkamp ^[8] ; Jonathan,Kallusky ^[8] ; Christine S,Falk ^[9] ; Tobias R,Overbeck ^[8] ; Stephanie,Heinemann ^[3]

作者单位： Department for Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.;German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany. ^[1] Department for Rheumatology and Immunology, Hannover Medical School, Hannover, Germany. ^[2] Department of General Practice, University Medical Center Göttingen, Humboldtallee 38, 37073, Göttingen, Germany. ^[3] Department for Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.;German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany.;CiiM-Centre for Individualised Infection Medicine, Hannover, Germany. ^[4] Department of General Practice, University Medical Center Göttingen, Humboldtallee 38, 37073, Göttingen, Germany. dominik.schroeder@med.uni-goettingen.de. ^[5] German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany.;Department of Computer Science, Ostfalia University of Applied Sciences, Wolfenbuettel, Germany. ^[6] Department of Computer Science, Ostfalia University of Applied Sciences, Wolfenbuettel, Germany. ^[7] Clinic for Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany. ^[8] German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany.;Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany. ^[9]

关键词 COVID-19 Checkpoint inhibition Coronavirus Elderly Hematology Humoral and cellular immunity Immunocompromised people Immunogenicity Pandemic SARS-CoV-2 Serological testing Social participation Solid tumor