Discovery of novel pleuromutilin derivatives as potent antibacterial agents.

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作者： Yuhang,Zhou ^[1] ; Yunpeng,Yi ^[2] ; Jiangkun,Wang ^[3] ; Zheng,Yang ^[4] ; Qinqin,Liu ^[4] ; Wanxia,Pu ^[4] ; Ruofeng,Shang ^[5]

作者单位： Key Laboratory of New Animal Drug Project, Gansu Province/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, 730050, China. Electronic address: zhouyuhangcaas@163.com. ^[1] Shandong Provincial Animal and Poultry Green Health Products Creation Engineering Laboratory, Institute of Poultry Science, Shandong Academy of Agricultural Science, 202 Gongyebeilu Jinan, 250023, Shandong, China. Electronic address: yiyp@foxmail.com. ^[2] School of Basic Medical Sciences, Lanzhou University, 730000, Lanzhou, China. ^[3] Key Laboratory of New Animal Drug Project, Gansu Province/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, 730050, China. ^[4] Key Laboratory of New Animal Drug Project, Gansu Province/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, 730050, China. Electronic address: shangrf1974@163.com. ^[5]

关键词 Antibacterial activity In vivo efficacy Molecular docking Pleuromutilin derivatives Synthesis