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首页> Investigational new drugs> NSC305787, a pharmacological ezrin inhibitor, exhibits antineoplastic activity in pancreatic cancer cells.

NSC305787, a pharmacological ezrin inhibitor, exhibits antineoplastic activity in pancreatic cancer cells.

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作者： Jean Carlos,Lipreri da Silva ^[1] ; Maria Fernanda Lopes,Carvalho ^[1] ; Livia Bassani Lins,de Miranda ^[1] ; Bruna Oliveira,de Almeida ^[1] ; Keli,Lima ^[1] ; João Agostinho,Machado-Neto ^[2]

作者单位： Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. ^[1] Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. ^[2] Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. jamachadoneto@usp.br. ^[3]

关键词 Antineoplastic activity Ezrin Functional genomics NSC305787 Pancreatic cancer

主题词金刚烷(Adamantane);腺癌(Adenocarcinoma);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞支架蛋白质类(Cytoskeletal Proteins);人类(Humans);胰腺肿瘤(Pancreatic Neoplasms);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);喹啉类(Quinolines)

DOI 10.1007/s10637-022-01249-z

PMID 35477813

发布时间 2023-12-13

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