Pheophorbide A and SN38 conjugated hyaluronan nanoparticles for photodynamic- and cascadic chemotherapy of cancer stem-like ovarian cancer.

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作者： Junghan,Lee ^[1] ; Enkhzaya,Davaa ^[2] ; Yixin,Jiang ^[1] ; Kyung-Ju,Shin ^[2] ; Min Hye,Kim ^[3] ; Hyunsu,An ^[4] ; Jinho,Kim ^[3] ; Steve K,Cho ^[4] ; Su-Geun,Yang ^[5]

作者单位： Department of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22212, Republic of Korea; Inha Institute of Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Republic of Korea. ^[1] Department of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22212, Republic of Korea. ^[2] Department of Chemistry, Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Republic of Korea. ^[3] School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea. ^[4] Department of Biomedical Science, BK21 FOUR Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22212, Republic of Korea; Inha Institute of Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Republic of Korea. Electronic address: sugeun.yang@inha.ac.kr. ^[5]

关键词 CD44-targeting Cancer stem cell (CSC) makers Chemo-resistant ovarian cancer Combination chemotherapy Hyaluronan nanoparticles Hyaluronan-cholesterol conjugate Photodynamic therapy SN38 Thioketal drug conjugate