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Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target.

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第一作者: Severin,Lechner
第一单位: Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
作者单位: Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. [1] Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA. [2] Animal Physiology and Immunology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. [3] Cancer Drug Development, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. [4] Computational Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. [5] Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany. [6] LipiTUM, Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. [7] Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich, Freising, Germany. [8] Cancer Drug Development, German Cancer Research Center (DKFZ), Heidelberg, Germany.;German Cancer Consortium (DKTK), Heidelberg, Germany. [9] Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.;Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich, Freising, Germany. [10] Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. g.medard@tum.de. [11]
DOI 10.1038/s41589-022-01015-5
PMID 35484434
发布时间 2024-09-01
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Nature chemical biology

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