Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization.

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第一作者： Ryan H,Moy

第一单位： Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA.

作者： Ryan H,Moy ^[1] ; Alexander,Nguyen ^[1] ; Jia Min,Loo ^[1] ; Norihiro,Yamaguchi ^[1] ; Christina M,Kajba ^[1] ; Balaji,Santhanam ^[2] ; Benjamin N,Ostendorf ^[1] ; Y Gloria,Wu ^[1] ; Saeed,Tavazoie ^[2] ; Sohail F,Tavazoie ^[3]

作者单位： Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA. ^[1] Department of Biochemistry and Molecular Biophysics and Department of Systems Biology, Columbia University, New York, NY 10032, USA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA. ^[2] Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: sohail.tavazoie@rockefeller.edu. ^[3]

关键词 ITPR3 RELB calcium colorectal cancer hypoxia metastasis non-canonical NF-κB

主题词钙(Calcium);结直肠肿瘤(Colorectal Neoplasms);人类(Humans);肌醇1,4,5-三磷酸受体(Inositol 1,4,5-Trisphosphate Receptors);肝肿瘤(Liver Neoplasms);NF-κB(NF-kappa B);转录因子RelB(Transcription Factor RelB)

DOI 10.1016/j.devcel.2022.04.010

PMID 35487218

发布时间 2023-12-02

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