Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling.

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作者： Megan J,Agajanian ^[1] ; Frances M,Potjewyd ^[2] ; Brittany M,Bowman ^[3] ; Smaranda,Solomon ^[4] ; Kyle M,LaPak ^[3] ; Dhaval P,Bhatt ^[3] ; Jeffery L,Smith ^[2] ; Dennis,Goldfarb ^[5] ; Alison D,Axtman ^[2] ; Michael B,Major ^[6]

作者单位： Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Cell Biology and Physiology, Washington University in St Louis, St Louis, Missouri, USA. ^[1] Division of Chemical Biology and Medicinal Chemistry, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. ^[2] Department of Cell Biology and Physiology, Washington University in St Louis, St Louis, Missouri, USA. ^[3] Institute for Informatics, School of Medicine, Washington University in St Louis, St Louis, Missouri, USA. ^[4] Department of Cell Biology and Physiology, Washington University in St Louis, St Louis, Missouri, USA; Institute for Informatics, School of Medicine, Washington University in St Louis, St Louis, Missouri, USA. ^[5] Department of Cell Biology and Physiology, Washington University in St Louis, St Louis, Missouri, USA; Department of Otolaryngology, School of Medicine, Washington University in St Louis, St Louis, Missouri, USA. Electronic address: bmajor@wustl.edu. ^[6]

关键词 WNT signaling casein kinase 1 gamma kinase inhibitor protein kinase proteomics

主题词酪蛋白激酶Ⅰ(Casein Kinase I);人类(Humans);磷酰化(Phosphorylation);Wnt蛋白质类(Wnt Proteins);β连环素(beta Catenin)

DOI 10.1016/j.jbc.2022.101986

PMID 35487243

发布时间 2024-09-23

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