Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.

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第一作者： Janet K,Jackman

第一单位： Department of Immunology Discovery, South San Francisco, Calif.

作者： Janet K,Jackman ^[1] ; Amy,Stockwell ^[2] ; David F,Choy ^[3] ; Markus M,Xie ^[1] ; Peipei,Lu ^[1] ; Guiquan,Jia ^[3] ; Hong,Li ^[4] ; Alexander R,Abbas ^[5] ; Paola G,Bronson ^[2] ; Wei-Yu,Lin ^[6] ; Cecilia P C,Chiu ^[6] ; Henry R,Maun ^[7] ; Merone,Roose-Girma ^[8] ; Lucinda,Tam ^[8] ; Juan,Zhang ^[9] ; Zora,Modrusan ^[10] ; Robert R,Graham ^[2] ; Timothy W,Behrens ^[2] ; Steven R,White ^[11] ; Ted,Naureckas ^[11] ; Carole,Ober ^[12] ; Manuel,Ferreira ^[13] ; Radislav,Sedlacek ^[14] ; Jiansheng,Wu ^[4] ; Wyne P,Lee ^[9] ; Robert A,Lazarus ^[7] ; James T,Koerber ^[6] ; Joseph R,Arron ^[1] ; Brian L,Yaspan ^[15] ; Tangsheng,Yi ^[16]

作者单位： Department of Immunology Discovery, South San Francisco, Calif. ^[1] Department of Human Genetics, South San Francisco, Calif. ^[2] Department of Biomarker Discovery OMNI, South San Francisco, Calif. ^[3] Department of Protein Chemistry, South San Francisco, Calif. ^[4] Department of Oncology Biomarker Development, South San Francisco, Calif. ^[5] Department of Antibody Engineering, South San Francisco, Calif. ^[6] Department of Early Discovery Biochemistry, South San Francisco, Calif. ^[7] Department of Molecular Biology, South San Francisco, Calif. ^[8] Department of Translational Immunology, South San Francisco, Calif. ^[9] Department of Microchemistry, Proteomics, Lipidomics and Next Generation Sequencing, Genentech Inc, South San Francisco, Calif. ^[10] Department of Medicine, Section of Pulmonary and Critical Care, Chicago, Ill. ^[11] Department of Human Genetics, University of Chicago, Chicago, Ill. ^[12] QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, Australia. ^[13] Labortory of Molecular Genetics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic. ^[14] Department of Human Genetics, South San Francisco, Calif. Electronic address: yaspan.brian@gene.com. ^[15] Department of Immunology Discovery, South San Francisco, Calif. Electronic address: tangsheng.yi@gilead.com. ^[16]

关键词 KLK5 SPINK5 T2-low asthma genome-wide association