SARS-CoV-2 Spike Protein Expression <i>In Vitro</i> and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19).

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作者： Richard,Stebbings ^[1] ; Christopher,Jones ^[2] ; Peter,Cotton ^[3] ; Gillian,Armour ^[4] ; Shaun,Maguire ^[4] ; Vicky,Skellett ^[2] ; Chi-Man,Tang ^[2] ; Joanne,Goodman ^[2] ; Tyler,Brady ^[5] ; Virginia,Takahashi ^[6] ; Andrew,Daunt ^[7] ; Jean-Martin,Lapointe ^[8] ; Taylor S,Cohen ^[6]

作者单位： Oncology Safety, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Melbourn, United Kingdom. ^[1] Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom. ^[2] Research and Development, BioPharmaceuticals R&D, AstraZeneca, Macclesfield, United Kingdom. ^[3] Regulatory Toxicology and Safety Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Melbourn, United Kingdom. ^[4] Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, United States. ^[5] Microbiome Discovery, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, United States. ^[6] Labcorp Early Development Laboratories Limited, Harrogate, United Kingdom. ^[7] Oncology Safety Pathology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom. ^[8]

关键词 AZD1222 (ChAdOx1 nCoV-19)COVID-19 vaccination SARS-CoV-2 spike protein adenovirus-vectored vaccine platelet and white blood cell parameters

主题词动物(Animals);抗体, 病毒(Antibodies, Viral);血液学(Hematology);人类(Humans);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);病毒疫苗(Viral Vaccines)

DOI 10.3389/fimmu.2022.836492

PMID 35493482

发布时间 2023-03-28

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