A Phase 1 Dose-Escalation Study of PF-06671008, a Bispecific T-Cell-Engaging Therapy Targeting P-Cadherin in Patients With Advanced Solid Tumors.

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第一作者： James J,Harding

第一单位： Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, United States.

作者： James J,Harding ^[1] ; Ignacio,Garrido-Laguna ^[2] ; Xiaoying,Chen ^[3] ; Cynthia,Basu ^[3] ; Afshin,Dowlati ^[4] ; Alison,Forgie ^[5] ; Andrea T,Hooper ^[6] ; Cris,Kamperschroer ^[7] ; Steven I,Max ^[8] ; Allison,Moreau ^[3] ; Megan,Shannon ^[3] ; Gilbert Y,Wong ^[5] ; David S,Hong ^[9]

作者单位： Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, United States. ^[1] Huntsman Cancer Institute at University of Utah, Salt Lake City, UT, United States. ^[2] Early Oncology Development and Clinical Research, Worldwide Research and Development, Pfizer, San Diego, CA, United States. ^[3] University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, OH, United States. ^[4] Early Clinical Development and Oncology Research, Worldwide Research and Development, Pfizer, San Francisco, CA, United States. ^[5] Oncology Research and Development, Pfizer, Inc., Pearl River, NY, United States. ^[6] Drug Safety Research and Development, Worldwide Research and Development, Pfizer, Groton, CT, United States. ^[7] Early Oncology Development and Clinical Research, Worldwide Research and Development, Pfizer, San Diego, CA, United States.;Janssen Pharmaceutical Companies of Johnson & Johnson, Philadelphia, PA, United States. ^[8] Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. ^[9]

关键词 P-cadherin T-cell–redirecting bispecific antibody cytokine release syndrome (CRS)immunotherapy phase 1 solid tumor

主题词成年人(Adult);抗体, 双特异性(Antibodies, Bispecific);钙黏着糖蛋白类(Cadherins);人类(Humans);肿瘤(Neoplasms);治疗结果(Treatment Outcome)

DOI 10.3389/fimmu.2022.845417

PMID 35493516

发布时间 2023-04-26

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