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Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: Diagnostic and therapeutic implications.

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第一作者： Panos,Theofilas

第一单位： Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.

作者： Panos,Theofilas ^[1] ; Antonia M H,Piergies ^[1] ; Ian,Oh ^[1] ; Yoo Bin,Lee ^[1] ; Song Hua,Li ^[1] ; Felipe L,Pereira ^[1] ; Cathrine,Petersen ^[1] ; Alexander J,Ehrenberg ^[1] ; Rana A,Eser ^[1] ; Andrew J,Ambrose ^[2] ; Brian,Chin ^[3] ; Teddy,Yang ^[3] ; Shireen,Khan ^[4] ; Raymond,Ng ^[4] ; Salvatore,Spina ^[1] ; Willian W,Seeley ^[5] ; Bruce L,Miller ^[6] ; Michelle R,Arkin ^[2] ; Lea T,Grinberg ^[7]

作者单位： Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA. ^[1] Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, USA. ^[2] Shanghai ChemPartner, Shanghai, China. ^[3] ChemPartner San Francisco, South San Francisco, California, USA. ^[4] Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.;Department of Pathology, University of California San Francisco, San Francisco, California, USA. ^[5] Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.;Global Brain Health Institute, University of California San Francisco, San Francisco, California, USA. ^[6] Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.;Department of Pathology, University of California San Francisco, San Francisco, California, USA.;Global Brain Health Institute, University of California San Francisco, San Francisco, California, USA.;Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil. ^[7]

关键词 Alzheimer's disease caspase-6 cell counting immunohistochemistry tau cleavage tau hyperphosphorylation tau isoforms tauopathies

医学主题词阿尔茨海默病(Alzheimer Disease);脑(Brain);半胱氨酸天冬氨酸蛋白酶6(Caspase 6);人类(Humans);神经元(Neurons);Tau病变(Tauopathies);tau蛋白质类(tau Proteins)

DOI 10.1111/nan.12819

PMID 35508761

发布时间 2026-03-07

基金项目

U54 NS100717/NS/NINDS NIH HHS/United States R01 AG075802/AG/NIA NIH HHS/United States R56 AG057528/AG/NIA NIH HHS/United States T32 GM139780/GM/NIGMS NIH HHS/United States P30 AG062422/AG/NIA NIH HHS/United States P01 AG019724/AG/NIA NIH HHS/United States K08 AG052648/AG/NIA NIH HHS/United States K01 AG053433/AG/NIA NIH HHS/United States U54 NS123746/NS/NINDS NIH HHS/United States K24 AG053435/AG/NIA NIH HHS/United States

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