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Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.

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第一作者: Aniket,Mishra
第一单位: University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, UMR 1219, F-33000 Bordeaux, France.
作者: Aniket,Mishra [1] ; Cécile,Duplaà [2] ; Dina,Vojinovic [3] ; Hideaki,Suzuki [4] ; Muralidharan,Sargurupremraj [1] ; Nuno R,Zilhão [5] ; Shuo,Li [6] ; Traci M,Bartz [7] ; Xueqiu,Jian [8] ; Wei,Zhao [9] ; Edith,Hofer [10] ; Katharina,Wittfeld [11] ; Sarah E,Harris [12] ; Sandra,van der Auwera-Palitschka [11] ; Michelle,Luciano [12] ; Joshua C,Bis [13] ; Hieab H H,Adams [14] ; Claudia L,Satizabal [15] ; Rebecca F,Gottesman [16] ; Piyush G,Gampawar [17] ; Robin,Bülow [18] ; Stefan,Weiss [19] ; Miao,Yu [9] ; Mark E,Bastin [20] ; Oscar L,Lopez [21] ; Meike W,Vernooij [22] ; Alexa S,Beiser [23] ; Uwe,Völker [19] ; Tim,Kacprowski [24] ; Aicha,Soumare [1] ; Jennifer A,Smith [9] ; David S,Knopman [25] ; Zoe,Morris [26] ; Yicheng,Zhu [27] ; Jerome I,Rotter [28] ; Carole,Dufouil [1] ; Maria,Valdés Hernández [29] ; Susana,Muñoz Maniega [30] ; Mark,Lathrop [31] ; Erik,Boerwinkle [32] ; Reinhold,Schmidt [33] ; Masafumi,Ihara [34] ; Bernard,Mazoyer [35] ; Qiong,Yang [36] ; Anne,Joutel [37] ; Elizabeth,Tournier-Lasserve [38] ; Lenore J,Launer [39] ; Ian J,Deary [12] ; Thomas H,Mosley [40] ; Philippe,Amouyel [41] ; Charles S,DeCarli [42] ; Bruce M,Psaty [43] ; Christophe,Tzourio [44] ; Sharon L R,Kardia [9] ; Hans J,Grabe [11] ; Alexander,Teumer [45] ; Cornelia M,van Duijn [46] ; Helena,Schmidt [17] ; Joanna M,Wardlaw [29] ; M Arfan,Ikram [47] ; Myriam,Fornage [48] ; Vilmundur,Gudnason [49] ; Sudha,Seshadri [50] ; Paul M,Matthews [51] ; William T,Longstreth [52] ; Thierry,Couffinhal [2] ; Stephanie,Debette [53]
作者单位: University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, UMR 1219, F-33000 Bordeaux, France. [1] University of Bordeaux, INSERM, Biologie des Maladies Cardiovasculaires, U1034, F-33600 Pessac, France. [2] Department of Epidemiology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands.;Department of Biomedical Data Sciences, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands. [3] Department of Cardiovascular Medicine, Tohoku University Hospital, 1-1, Seiryo, Aoba, Sendai 980-8574, Japan.;Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryo, Aoba, Sendai 980-8573, Japan.;Department of Brain Sciences and UK Dementia Research Institute Centre, Imperial College, London, W12 0NN, UK. [4] Icelandic Heart Association, 200 Kopavogur, Iceland. [5] Department of Biostatistics, Boston University School of Public Health, Boston, MA 02115, USA. [6] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA.;Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. [7] Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.;Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA. [8] Department of Epidemiology, School of Public Health, University of Michigan, Michigan, MI 48104, USA. [9] Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria.;Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria. [10] German Centre for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, 17489 Greifswald, Germany.;Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany. [11] Department of Psychology, University of Edinburgh, EH8 9JZ Edinburgh, UK. [12] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA. [13] Department of Epidemiology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands.;Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands.;Department of Clinical Genetics, Erasmus University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands. [14] Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.;The Framingham Heart Study, Framingham, MA 01701, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA 2115, USA. [15] National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD 20814, USA. [16] Institute of Molecular Biology & Biochemistry, Gottfried Schatz Research Centre (for Cell Signalling, Metabolism and Aging), Medical University of Graz, 8036 Graz, Austria. [17] Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17489 Greifswald, Germany. [18] Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17489 Greifswald, Germany. [19] Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH8 9AB, UK.;Division of Neuroimaging Sciences, Brain Research Imaging Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK. [20] Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.;Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA. [21] Department of Epidemiology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands.;Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands. [22] Department of Biostatistics, Boston University School of Public Health, Boston, MA 02115, USA.;The Framingham Heart Study, Framingham, MA 01701, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA 2115, USA. [23] Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17489 Greifswald, Germany.;TUM School of Life Sciences Weihenstephan (WZW), Technical University of Munich (TUM), 85354 Freising-Weihenstephan, Germany. [24] Mayo Clinic, Rochester, MN 55905, USA. [25] Neuroradiology Department, Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK. [26] Department of Neurology, Peking Union Medical College Hospital, Beijing 100730, China. [27] The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. [28] Division of Neuroimaging Sciences, Brain Research Imaging Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK. [29] Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH8 9AB, UK. [30] University of McGill Genome Center, Montreal, Quebec H3A 0G1, Canada. [31] Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. [32] Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria. [33] Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Osaka 564-8565, Japan. [34] University of Bordeaux, Institut des Maladies Neurodégénératives, CNRS-CEA UMR 5293, 33000 Bordeaux, France. [35] Department of Biostatistics, Boston University School of Public Health, Boston, MA 02115, USA.;The Framingham Heart Study, Framingham, MA 01701, USA. [36] Institute of Psychiatry and Neurosciences of Paris, INSERM UMR1266, Université de Paris, France. [37] Université de Paris, INSERM UMR-1141 Neurodiderot, Paris F-75019, France. [38] Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. [39] Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS 39216, USA. [40] University of Lille, INSERM, Institut Pasteur de Lille, UMR1167-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, F-59000 Lille, France.;LabEx DISTALZ, Institut Pasteur de Lille, 59000 Lille, France.;Department of Epidemiology and Public Health, Centre Hospital University of Lille, F-59000 Lille, France. [41] Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA 95816, USA. [42] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.;Department of Health Systems and Population Health, University of Washington, Seattle, WA. [43] University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, UMR 1219, F-33000 Bordeaux, France.;CHU de Bordeaux, Pole de santé publique, Service d'information médicale, F-33000 Bordeaux, France. [44] Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany. [45] Department of Biomedical Data Sciences, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands.;Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK. [46] Department of Biomedical Data Sciences, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands.;Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands. [47] Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.;Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. [48] Icelandic Heart Association, 200 Kopavogur, Iceland.;Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland. [49] Department of Epidemiology, School of Public Health, University of Michigan, Michigan, MI 48104, USA.;The Framingham Heart Study, Framingham, MA 01701, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA 2115, USA. [50] Department of Brain Sciences and UK Dementia Research Institute Centre, Imperial College, London, W12 0NN, UK. [51] Department of Epidemiology, University of Washington, Seattle, WA, USA.;Department of Neurology, University of Washington, Seattle, WA 98104-2420, USA. [52] University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, UMR 1219, F-33000 Bordeaux, France.;Department of Neurology, Boston University School of Medicine, Boston, MA 2115, USA.;CHU de Bordeaux, Department of Neurology, F-33000 Bordeaux, France. [53]
DOI 10.1093/brain/awab432
PMID 35511193
发布时间 2023-10-01
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Brain : a journal of neurology

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