Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.

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作者： Xiufen,Liu ^[1] ; Masanori,Onda ^[1] ; Nathan,Watson ^[1] ; Raffit,Hassan ^[2] ; Mitchell,Ho ^[1] ; Tapan K,Bera ^[1] ; Junxia,Wei ^[1] ; Anirban,Chakraborty ^[1] ; Richard,Beers ^[1] ; Qi,Zhou ^[1] ; Asif,Shajahan ^[3] ; Parastoo,Azadi ^[3] ; Jingyu,Zhan ^[4] ; Di,Xia ^[4] ; Ira,Pastan ^[1]

作者单位： Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264. ^[1] Thoracic and GI Malignancies Branch, NCI, Bethesda, MD 20892. ^[2] Analytical Services and Training, University of Georgia, Athens, GA 30602-4712. ^[3] Laboratory of Cell Biology, NCI, Bethesda, MD 20892-4255. ^[4]

关键词 antibody cancer immunotherapy ovarian cancer pancreatic cancer

主题词抗体, 单克隆(Antibodies, Monoclonal);细胞系, 肿瘤(Cell Line, Tumor);GPI连接蛋白质类(GPI-Linked Proteins);T淋巴细胞(T-Lymphocytes)

DOI 10.1073/pnas.2202439119

PMID 35512094

发布时间 2024-09-23

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